Background The use of angiotensin II inhibitors is associated with a low risk of recurrence
and metastasis in hepatocellular carcinoma (HCC) patients. Vascular cell adhesion …

Angiotensin II type 1 receptor (AT1R) was reported to express in many types of tumors,
promoting tumor growth and angiogenesis. We herein examined AT1R expression in liver …

The aim of this study was to observe the effect of interferon alpha (IFNα) on tumor
endothelial cells (TECs) in highly metastatic hepatocellular carcinoma (HCC) model, and to …

Angiogenesis is a complex and critical process essential for supporting the growth of
hepatocellular carcinoma (HCC) as well as hepatocarcinogenesis. Recent studies have …

Liver metastases from colorectal cancer (CRC) are a clinically significant problem. The renin–
angiotensin system is involved in tumor growth and metastases. This study was designed to …

Increasing evidence suggests that the renin-angiotensin system (RAS) plays an important
role in tumorigenesis. The interaction between Angiotensin II (AngII) and angiotensin type 1 …

Antiangiogenic therapy, specially sorafenib, has become the standard of care for patients
with advanced hepatocellular carcinoma (HCC), however, the improvement in survival time …

The poor prognosis and recurrence of HCC are majorly caused by intrahepatic metastasis.
Delineating the molecular pathways mediating these processes may benefit developing …

Purpose Emerging evidence indicates that combining Sorafenib with vitamin K1 (VK1) may
result in a synergistic inhibition of hepatocellular carcinoma (HCC) cell migration and …

Metastasis is responsible for the great majority of deaths in cancer patients. Matrix
metalloproteinases (MMPs) have critical functions in cancer metastasis. Especially, MMP-2 …