Malaria is a preventable and curable disease known to be caused by the parasitic infection
of Plasmodium spp., which is transmitted through the bites of infected female Anopheles …

Recent initiatives to develop more effective and affordable drugs, controlling mosquitoes
and development of a preventative vaccine have been launched with the goal of completely …

Background: Malaria is responsible for social and economic burden in most lowincome
malaria-affected countries. Thus, newer antimalarials are needed to tackle morbidities and …

The 2-phenylbenzimidazole scaffold has recently been discovered to inhibit β-hematin
(synthetic hemozoin) formation by high throughput screening. Here, a library of 325,728 N-4 …

In a previous study, target based screening was carried out for inhibitors of β-hematin
(synthetic hemozoin) formation, and a series of triarylimidazoles were identified as active …

The growing drug resistance of Plasmodia spp. to current antimalarial agents in the quinine
and artemisinin families further asserts the need for novel drug classes to combat malaria …

The emergence of drug resistant strains of Plasmodium spp. creates a critical need for the
development of novel antimalarials. Formation of hemozoin, a crystalline heme …

Clinical manifestations of malaria primarily result from proliferation of the parasite within the
hosts' erythrocytes. During this process, hemoglobin is utilized as the predominant source of …

Malaria remains a major public health problem. With the loss of antimalarials to resistance,
the malaria burden will likely continue for decades. New antimalarial scaffolds are crucial to …

Abstract The Malaria Box, assembled by the Medicines for Malaria Venture, is a set of 400
structurally diverse, commercially available compounds with demonstrated activity against …