Predictive models of immune protection from COVID-19 are urgently needed to identify
correlates of protection to assist in the future deployment of vaccines. To address this, we …

Both previous infection and vaccination have been shown to provide potent protection from
COVID-19. However, there are concerns that waning immunity and viral variation may lead …

The global supply of COVID-19 vaccines remains limited. An understanding of the immune
response that is predictive of protection could facilitate rapid licensure of new vaccines. Data …

A correlate of protection for SARS-CoV-2 vaccines is urgently needed | Nature Medicine Skip to
main content Thank you for visiting nature.com. You are using a browser version with limited …

SARS-CoV-2 escaped natural immunity, raising questions about vaccines and therapies |
Nature Medicine Skip to main content Thank you for visiting nature.com. You are using a …

Understanding antibody-based SARS-CoV-2 immunity is critical for overcoming the COVID-
19 pandemic and informing vaccination strategies. We evaluated SARS-CoV-2 antibody …

Summary Background Several SARS-CoV-2 variants of concern have been identified that
partly escape serum neutralisation elicited by current vaccines. Studies have also shown …

Antibody-dependent enhancement (ADE) of disease is a general concern for the
development of vaccines and antibody therapies because the mechanisms that underlie …

Antibodies elicited in response to infection undergo somatic mutation in germinal centers
that can result in higher affinity for the cognate antigen. To determine the effects of somatic …

Current coronavirus disease 2019 (COVID-19) vaccines effectively reduce overall morbidity
and mortality and are vitally important to controlling the pandemic. Individuals who …