Frailty is a clinical state characterized by an age-related unsteady state of the body, a
decline in physiological function, and an increased vulnerability to adverse outcomes. Early …

Frailty is a common geriatric syndrome and a risk factor for many diseases, even mortality.
However, the specific molecular biomarkers for diagnosis and therapeutic targets of frailty …

Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

Introduction: Frailty is consequent to age-dependent deregulation of several biological
pathways and systems, encompassing namely sarcopenia, age-associated hormonal …

Aging is a dynamic process depending on intrinsic and extrinsic factors and its evolution is a
continuum of transitions, involving multifaceted processes at multiple levels. It is recognized …

Several biomarkers have been proposed to identify frailty, a multisystemic age-related
syndrome. However, the complex pathophysiology and the absence of a consensus on a …

Introduction: Although frailty is a geriatric syndrome that is associated with disability,
hospitalization, and mortality, it can be reversible and preventable with the appropriate …

An increase in the number of older people experiencing disability and dependence is a
critical aspect of the demographic change that will emerge within Europe due to the rise in …

Frailty is a state of decreased physiological reserve and increased vulnerability to adverse
outcomes in aging, and is characterized by dysregulation across various biological …

Background/Objectives Owing to accelerated population aging, health in older adults is
becoming increasingly important. Frailty can reflect the health status and disease risks of …