Macrophages inhibit adipogenic differentiation of adipose tissue derived mesenchymal stem/stromal cells by producing pro-inflammatory cytokines

H Ma, Y Li, L Song, R Liu, X Li, Q Shang, Y Wang… - Cell & bioscience, 2020 - Springer
Background Mesenchymal stem/stromal cells (MSCs) and macrophages are critical
components in many tissue microenvironments, including that in adipose tissue. The close …

Human adipose mesenchymal stem cells modulate myeloid cells toward an anti-inflammatory and reparative phenotype: role of IL-6 and PGE2

M Ortiz-Virumbrales, R Menta, LM Pérez… - Stem Cell Research & …, 2020 - Springer
Abstract Background Mesenchymal stem cells (MSCs) activate the endogenous immune
regulatory system, inducing a therapeutic effect in recipients. MSCs have demonstrated the …

Adipose‐derived mesenchymal stem cells promote M2 macrophage phenotype through exosomes

JS Heo, Y Choi, HO Kim - Stem cells international, 2019 - Wiley Online Library
Accumulating evidence has shown that the paracrine factors derived from mesenchymal
stem cells (MSCs) are capable of regulating the immune system via interaction with various …

Adipose-derived mesenchymal stromal cells modulate lipid metabolism and lipid droplet biogenesis via AKT/mTOR–PPARγ signalling in macrophages

L Souza-Moreira, VC Soares, SSG Dias, PT Bozza - Scientific reports, 2019 - nature.com
Mesenchymal stromal cells (MSCs) are a potential therapy for many chronic inflammatory
diseases due to their regenerative, immunologic and anti-inflammatory properties. The two …

Paracrine anti-inflammatory effects of adipose tissue-derived mesenchymal stem cells in human monocytes

MI Guillén, J Platas, MD Perez del Caz… - Frontiers in …, 2018 - frontiersin.org
The inflammatory process is an essential phenomenon in the induction of immune
responses. Monocytes are key effector cells during the inflammatory process. A wide range …

Impaired immunomodulatory capacity in adipose tissue‐derived mesenchymal stem/stromal cells isolated from obese patients

XY Zhu, N Klomjit, SM Conley, MM Ostlie… - Journal of cellular …, 2021 - Wiley Online Library
Immune‐modulatory properties of adipose tissue‐derived mesenchymal stem/stromal cells
(MSCs) might be susceptible to metabolic disturbances. We hypothesized that the immune …

Adipogenic differentiation of mesenchymal stem cells alters their immunomodulatory properties in a tissue-specific manner

H Munir, LSC Ward, L Sheriff, S Kemble, S Nayar… - Stem …, 2017 - academic.oup.com
Chronic inflammation is associated with formation of ectopic fat deposits that might represent
damage-induced aberrant mesenchymal stem cell (MSC) differentiation. Such deposits are …

Induction of macrophage M2b/c polarization by adipose tissue‐derived mesenchymal stem cells

M Sun, L Sun, C Huang, B Chen… - Journal of immunology …, 2019 - Wiley Online Library
Background. Adipose‐derived mesenchymal stem cells (ADMSCs) can promote healing and
inhibit inflammation/immune response in local tissues, while the detailed mechanism …

In Vitro Culture Expansion Shifts the Immune Phenotype of Human Adipose-Derived Mesenchymal Stem Cells

R Jeske, X Yuan, Q Fu, BA Bunnell… - Frontiers in …, 2021 - frontiersin.org
Human mesenchymal stem or stromal cells (hMSCs) are known for their potential in
regenerative medicine due to their differentiation abilities, secretion of trophic factors, and …

Effects of continuous passage on immunomodulatory properties of human adipose-derived stem cells

X Wang, C Liu, S Li, Y Xu, P Chen, Y Liu, Q Ding… - Cell and tissue …, 2015 - Springer
Human adipose-derived stem cells (hADSCs) have the ability to influence immune
response, and hence are key cell sources for tissue repair and regeneration. In this study we …