Age-related dedifferentiation and hyperdifferentiation of perceptual and mnemonic representations

L Deng, SW Davis, ZA Monge, EA Wing, BR Geib… - Neurobiology of …, 2021 - Elsevier
Preliminary evidence indicates that occipito-temporal activation patterns for different visual
stimuli are less distinct in older (OAs) than younger (YAs) adults, suggesting a …

Age differences in neural distinctiveness revealed by multi-voxel pattern analysis

J Carp, J Park, TA Polk, DC Park - Neuroimage, 2011 - Elsevier
Current theories of cognitive aging argue that neural representations become less distinctive
in old age, a phenomenon known as dedifferentiation. The present study used multi-voxel …

Effects of aging on successful object encoding: enhanced semantic representations compensate for impaired visual representations

L Naspi, C Stensholt, AE Karlsson… - Journal of …, 2023 - Soc Neuroscience
Although episodic memory and visual processing decline substantially with healthy aging,
semantic knowledge is generally spared. There is evidence that older adults9 spared …

Sensory representations supporting memory specificity: Age effects on behavioral and neural discriminability

CR Bowman, JD Chamberlain… - Journal of …, 2019 - Soc Neuroscience
Older adults' difficulty in distinguishing between old and new information contributes to
memory decline, which may occur because older adults are less likely than young adults to …

Dissociative effects of age on neural differentiation at the category and item levels

S Srokova, ANZ Aktas, JD Koen… - Journal of …, 2024 - Soc Neuroscience
Increasing age is associated with age-related neural dedifferentiation, a reduction in the
selectivity of neural representations, which has been proposed to contribute to cognitive …

Dedifferentiation in the visual cortex: an fMRI investigation of individual differences in older adults

MW Voss, KI Erickson, L Chaddock, RS Prakash… - Brain research, 2008 - Elsevier
Dedifferentiation, or decreased processing specificity, has been suggested to represent a
ubiquitous characteristic of cognitive aging. In this study, we examined both age-related …

Age-related declines in neural distinctiveness correlate across brain areas and result from both decreased reliability and increased confusability

M Simmonite, TA Polk - Aging, Neuropsychology, and Cognition, 2022 - Taylor & Francis
According to the neural dedifferentiation hypothesis, age-related reductions in the
distinctiveness of neural representations contribute to sensory, cognitive, and motor declines …

Tracking age differences in neural distinctiveness across representational levels

M Kobelt, VR Sommer, A Keresztes… - Journal of …, 2021 - Soc Neuroscience
The distinctiveness of neural information representation is crucial for successful memory
performance but declines with advancing age. Computational models implicate age-related …

Age differences in neural distinctiveness during memory encoding, retrieval, and reinstatement

C Pauley, M Kobelt, M Werkle-Bergner… - Cerebral …, 2023 - academic.oup.com
Robust evidence points to mnemonic deficits in older adults related to dedifferentiated, ie
less distinct, neural responses during memory encoding. However, less is known about …

The relationship between age, neural differentiation, and memory performance

JD Koen, N Hauck, MD Rugg - Journal of Neuroscience, 2019 - Soc Neuroscience
Healthy aging is associated with decreased neural selectivity (dedifferentiation) in category-
selective cortical regions. This finding has prompted the suggestion that dedifferentiation …