Endothelial injury and thrombotic microangiopathy in COVID-19: Treatment with the lectin-pathway inhibitor narsoplimab

A Rambaldi, G Gritti, MC Micò, M Frigeni, G Borleri… - Immunobiology, 2020 - Elsevier
In COVID-19, acute respiratory distress syndrome (ARDS) and thrombotic events are
frequent, life-threatening complications. Autopsies commonly show arterial thrombosis and …

Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation

SX Gu, T Tyagi, K Jain, VW Gu, SH Lee… - Nature Reviews …, 2021 - nature.com
The core pathology of coronavirus disease 2019 (COVID-19) is infection of airway cells by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that results in excessive …

Increased levels of inflammatory and endothelial biomarkers in blood of long COVID patients point to thrombotic endothelialitis

S Turner, CA Naidoo, TJ Usher… - … in Thrombosis and …, 2024 - thieme-connect.com
The prevailing hypotheses for the persistent symptoms of Long COVID have been narrowed
down to immune dysregulation and autoantibodies, widespread organ damage, viral …

The emerging threat of (micro) thrombosis in COVID-19 and its therapeutic implications

JD McFadyen, H Stevens, K Peter - Circulation research, 2020 - Am Heart Assoc
The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
and the ensuing global pandemic has presented a health emergency of unprecedented …

Endothelial cell–activating antibodies in COVID‐19

H Shi, Y Zuo, S Navaz, A Harbaugh… - Arthritis & …, 2022 - Wiley Online Library
Objective While endothelial dysfunction has been implicated in the widespread
thromboinflammatory complications of COVID‐19, the upstream mediators of …

Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19

A Bonaventura, A Vecchié, L Dagna… - Nature Reviews …, 2021 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is a clinical syndrome caused by infection
with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with severe …

Anticipating and managing coagulopathy and thrombotic manifestations of severe COVID-19

LC Godoy, EC Goligher, PR Lawler, AS Slutsky… - Cmaj, 2020 - Can Med Assoc
CMAJ| OCTOBER 5, 2020| VOLUME 192| ISSUE 40 E1157 in thrombotic microangiopathy
by inducing tissue factor expression, secretion of von Willebrand factor, and secretion and …

[HTML][HTML] Sustained inflammation, coagulation activation and elevated endothelin-1 levels without macrovascular dysfunction at 3 months after COVID-19

LH Willems, M Nagy, H Ten Cate, HMH Spronk… - Thrombosis research, 2022 - Elsevier
Introduction Endothelial damage and thrombosis caused by COVID-19 may imperil
cardiovascular health. More than a year since the WHO declared COVID-19 pandemic …

Biomarkers of endothelial dysfunction and outcomes in coronavirus disease 2019 (COVID-19) patients: A systematic review and meta-analysis

MJ Al-Farabi, RA Nugraha, BA Marsudi, Y Azmi - Microvascular research, 2021 - Elsevier
Background Several studies have reported that the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) can directly infect endothelial cells, and endothelial …

[HTML][HTML] COVID-19 vasculopathy: mounting evidence for an indirect mechanism of endothelial injury

RF Nicosia, G Ligresti, N Caporarello, S Akilesh… - The American journal of …, 2021 - Elsevier
Patients with coronavirus disease 2019 (COVID-19) who are critically ill develop vascular
complications characterized by thrombosis of small, medium, and large vessels. Dysfunction …