Vascular tissues express arginase that metabolizes l-arginine to l-ornithine and urea and
thus reduces substrate availability for nitric oxide formation. Dahl salt-sensitive (Dahl-S) rats …

Objective High vascular arginase activity and subsequent reduction in vascular nitric oxide
production were recently reported in animal models of hypertension. The present study …

There is growing evidence that vascular arginase plays a role in pathophysiology of
vascular diseases. We recently reported high arginase activity/expression in young adult …

Objective This study investigated whether arginase contributes to endothelial dysfunction
and hypertension in obese rats. Methods Endothelial function and arginase expression were …

Objective A decrease in nitric oxide (NO) bioavailability has been proposed to contribute to
endothelial dysfunction and increased peripheral resistances during essential arterial …

Aims Growing evidence suggests that arginase misregulation plays a key role in the
pathophysiology of essential hypertension. In the present study, we investigated the …

One characteristic of hypertension is a decreased endothelium-dependent nitric oxide (NO)-
mediated vasodilation; however, the underlying mechanism is complex. In endothelial cells …

Enhanced arginase (ARG) activity has been identified as a factor that reduces nitric oxide
production and impairs endothelial function in vascular pathologies. Using a gene deletion …

Increased arginase activity has been reported in a variety of disease conditions
characterized by vascular dysfunction. In the present study, the potentially protective effect of …

Arginase may play a major role in the regulation of vascular function in various
cardiovascular disorders by impairing nitric oxide (NO) production. In the current study, we …