Menopause is not only the end of reproductive life, it is also related to diseases such as
hyperlipidaemia, atherosclerotic cardiovascular disease, osteoporosis and breast cancer …

Background Age at natural menopause (ANM) is an important index for women's health.
Either early or late ANM is associated with a series of adverse outcomes later in life. Despite …

The age at natural menopause shows great variability. It has been proposed that early age
at menopause is a risk factor for osteoporosis and cardiovascular disease, whereas later …

BACKGROUND Timing of natural menopause has great implications for fertility and
women's health. Age at natural menopause (ANM) is largely influenced by genetic factors. In …

To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22
genome-wide association studies (GWAS) in 38,968 women of European descent, with …

Menopause is defined as the permanent cessation of ovulation and hence menstruation due
to ovarian failure. The median age of menopause is 51 years. However, early menopause …

Early menopause (EM) affects up to 10% of the female population, reducing reproductive
lifespan considerably. Currently, it constitutes the leading cause of infertility in the western …

Menopause is a biological event associated with the complete cessation of a woman's
reproductive ability. Early menopause is defined as entry into menopause between the ages …

Background Age at natural menopause (ANM) is a complex trait with high heritability and is
associated with several major hormonal-related diseases. Recently, several genome-wide …

STUDY QUESTION Do differences in heritable genetic factors explain some of the difference
in age at natural menopause (ANM) among populations? SUMMARY ANSWER One single …