Blockade of intercellular adhesion molecule-1 prevents angiotensin II-induced hypertension and vascular dysfunction

PP Lang, J Bai, YL Zhang, XL Yang, YL Xia… - Laboratory …, 2020 - nature.com
Monocyte and adhesion infiltration into the arterial subendothelium are initial steps in
hypertension development. The endothelial intercellular adhesion molecule-1 (ICAM-1) has …

Upregulated expression of rat heart intercellular adhesion molecule-1 in angiotensin II–but not phenylephrine-induced hypertension

A Kiarash, PJ Pagano, M Tayeh, NE Rhaleb… - …, 2001 - Am Heart Assoc
Intercellular adhesion molecule-1 (ICAM-1), part of an immunoglobulin-like superfamily of
adhesion molecules, is involved in several cardiovascular diseases. We investigated …

Pharmacological blockage of ICAM-1 improves angiotensin II-induced cardiac remodeling by inhibiting adhesion of LFA-1+ monocytes

QY Lin, PP Lang, YL Zhang, XL Yang… - American Journal …, 2019 - journals.physiology.org
Intercellular adhesion molecule-1 (ICAM-1) is a member of an immunoglobulin-like
superfamily of adhesion molecules that mediate leukocyte adhesion to vascular …

Angiotensin II stimulates intercellular adhesion molecule-1 (ICAM-1) expression by human vascular endothelial cells and increases soluble ICAM-1 release in vivo

L Pastore, A Tessitore, S Martinotti, E Toniato… - Circulation, 1999 - Am Heart Assoc
Background—We evaluated whether angiotensin II (Ang II) influenced intercellular adhesion
molecule (ICAM)-1 expression by human vascular endothelial cells derived from umbilical …

Roles of intercellular adhesion molecule-1 in hypertensive cardiac remodeling

F Kuwahara, H Kai, K Tokuda, H Niiyama, N Tahara… - …, 2003 - Am Heart Assoc
Recently, we have shown that in rats with a suprarenal abdominal aortic constriction (AC),
pressure overload induces early perivascular fibro-inflammatory changes (transforming …

Effects of chronic arterial hypertension on constitutive and induced intercellular adhesion molecule-1 expression in vivo

S Komatsu, J Panés, JM Russell, DC Anderson… - …, 1997 - Am Heart Assoc
Recent reports indicate that bacterial endotoxin (lipopolysaccharide) and cytokines elicit a
more profound increase in the surface expression of intercellular adhesion molecule-1 …

Blocking VCAM-1 prevents angiotensin II-induced hypertension and vascular remodeling in mice

L Yin, J Bai, WJ Yu, Y Liu, HH Li, QY Lin - Frontiers in pharmacology, 2022 - frontiersin.org
Adhesion of monocytes to the vascular endothelium frequently leads to an inflammatory
response, which contributes to hypertension and vascular remodeling. Vascular cellular …

The upregulation of ICAM-1 and P-selectin requires high blood pressure but not circulating renin–angiotensin system in vivo

H Wang, J Nawata, N Kakudo, K Sugimura… - Journal of …, 2004 - journals.lww.com
Objective To investigate the separate contributions of blood pressure and the circulating
renin–angiotensin system to the upregulation of vascular endothelial adhesion molecules in …

Angiotensin II induces vascular cell adhesion molecule-1 expression in rat vasculature: a potential link between the renin-angiotensin system and atherosclerosis

PE Tummala, XL Chen, CL Sundell, JB Laursen… - Circulation, 1999 - Am Heart Assoc
Background—Cardiovascular ischemic events may occur more frequently in hypertensive
patients with activated renin-angiotensin systems. We tested the hypothesis that angiotensin …

Effects of cross-linking ICAM-1 on the surface of human vascular smooth muscle cells: induction of VCAM-1 but no proliferation

C Lawson, ME Ainsworth, AM McCormack… - Cardiovascular …, 2001 - academic.oup.com
Objective: Intercellular adhesion molecule (ICAM)-1 is an immunoglobulin-like cell adhesion
molecule expressed by several cell types, including proliferating vascular smooth muscle …