Endothelial dysfunction is a characteristic feature in diabetes that contributes to the
development of vascular disease. Recently, arginase has been implicated in triggering …

Diabetes mellitus is a major risk factor for the development of cardiovascular disease due to
increased vascular inflammatory and oxidative stress favouring atherogenesis. Endothelial …

Arginase can cause vascular dysfunction by competing with nitric oxide synthase for l-
arginine and by increasing cell proliferation and collagen formation, which promote vascular …

Background Elevated arginase (Arg) activity is reported to be involved in diabetes-induced
vascular endothelial dysfunction. It can reduce L-arginine availability to nitric oxide (NO) …

Coronary artery disease (CAD) remains the leading cause of death in the Western societies.
Diabetes mellitus (DM) is one of the highly prevalent diseases, which remarkably …

Objective This study investigated whether arginase contributes to endothelial dysfunction
and hypertension in obese rats. Methods Endothelial function and arginase expression were …

Background: Endothelial dysfunction contributes to the development of vascular
complication in diabetes. Arginase has emerged as a key mechanism behind endothelial …

Aims Elevation of arginase activity has been linked to vascular dysfunction in diabetes and
hypertension by a mechanism involving decreased nitric oxide (NO) bioavailability due to L …

Background Cardiovascular disorders associated with endothelial dysfunction, such as
atherosclerosis, have decreased nitric oxide (NO) bioavailability. Arginase in the vasculature …

Endothelial dysfunction represents an early change in the vascular wall in areas prone to
atherosclerotic plaque formation and is present in association with several risk factors for …