SARS-CoV-2 viral proteins NSP1 and NSP13 inhibit interferon activation through distinct mechanisms

C Vazquez, SE Swanson, SG Negatu, M Dittmar… - PloS one, 2021 - journals.plos.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a devastating
global pandemic, infecting over 43 million people and claiming over 1 million lives, with …

Ubiquitination of SARS-CoV-2 NSP6 and ORF7a facilitates NF-κB activation

H Nishitsuji, S Iwahori, M Ohmori, K Shimotohno… - MBio, 2022 - Am Soc Microbiol
Patients with severe coronavirus disease 2019 tend to have high levels of proinflammatory
cytokines, which eventually lead to cytokine storm and the development of acute respiratory …

Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein

JCC Hsu, M Laurent-Rolle, JB Pawlak… - Proceedings of the …, 2021 - National Acad Sciences
The ongoing COVID-19 pandemic has caused an unprecedented global health crisis.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of …

Evasion of type I interferon by SARS-CoV-2

H Xia, Z Cao, X Xie, X Zhang, JYC Chen, H Wang… - Cell reports, 2020 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication and host
immune response determine coronavirus disease 2019 (COVID-19), but studies evaluating …

Roles and functions of SARS-CoV-2 proteins in host immune evasion

F Rashid, Z Xie, M Suleman, A Shah, S Khan… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades the host immune
system through a variety of regulatory mechanisms. The genome of SARS-CoV-2 encodes …

[HTML][HTML] SARS-CoV-2 main protease suppresses type I interferon production by preventing nuclear translocation of phosphorylated IRF3

SY Fung, KL Siu, H Lin, ML Yeung… - International Journal of …, 2021 - ncbi.nlm.nih.gov
Suppression of type I interferon (IFN) response is one pathological outcome of the infection
of highly pathogenic human coronaviruses. To effect this, severe acute respiratory syndrome …

SARS-CoV-2 nonstructural protein 1 inhibits the interferon response by causing depletion of key host signaling factors

A Kumar, R Ishida, T Strilets, J Cole… - Journal of …, 2021 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the ongoing coronavirus disease 2019 (COVID-19) pandemic. While previous studies have …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) and spike (S) proteins antagonize host type I interferon response

Q Zhang, Z Chen, C Huang, J Sun, M Xue… - Frontiers in cellular …, 2021 - frontiersin.org
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has spread worldwide and has infected more than 250 million …

SARS-CoV-2 nsp12 attenuates type I interferon production by inhibiting IRF3 nuclear translocation

W Wang, Z Zhou, X Xiao, Z Tian, X Dong… - Cellular & molecular …, 2021 - nature.com
SARS-CoV-2 is the pathogenic agent of COVID-19, which has evolved into a global
pandemic. Compared with some other respiratory RNA viruses, SARS-CoV-2 is a poor …

SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists

CK Yuen, JY Lam, WM Wong, LF Mak… - Emerging microbes & …, 2020 - Taylor & Francis
ABSTRACT The Coronavirus disease 2019 (COVID-19), which is caused by the novel SARS-
CoV-2 virus, is now causing a tremendous global health concern. Since its first appearance …