Blocking VCAM-1 prevents angiotensin II-induced hypertension and vascular remodeling in mice

L Yin, J Bai, WJ Yu, Y Liu, HH Li, QY Lin - Frontiers in pharmacology, 2022 - frontiersin.org
Adhesion of monocytes to the vascular endothelium frequently leads to an inflammatory
response, which contributes to hypertension and vascular remodeling. Vascular cellular …

Blocking VCAM-1 ameliorates hypertensive cardiac remodeling by impeding macrophage infiltration

ZY Qiu, WJ Yu, J Bai, QY Lin - Frontiers in Pharmacology, 2022 - frontiersin.org
Cardiac remodeling is an important mechanism of heart failure, which frequently results from
leukocyte infiltration. Vascular cellular adhesion molecule-1 (VCAM-1) plays a critical role in …

Blockade of intercellular adhesion molecule-1 prevents angiotensin II-induced hypertension and vascular dysfunction

PP Lang, J Bai, YL Zhang, XL Yang, YL Xia… - Laboratory …, 2020 - nature.com
Monocyte and adhesion infiltration into the arterial subendothelium are initial steps in
hypertension development. The endothelial intercellular adhesion molecule-1 (ICAM-1) has …

Targeting VCAM-1: a therapeutic opportunity for vascular damage

MF Troncoso, MC Díaz-Vesga… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction The vascular cell adhesion molecule (VCAM-1) is a transmembrane
sialoglycoprotein detected in activated endothelial and vascular smooth muscle cells …

Targeting endothelial vascular cell adhesion molecule-1 in atherosclerosis: drug discovery and development of vascular cell adhesion molecule-1–directed novel …

JR Pickett, Y Wu, LF Zacchi, HT Ta - Cardiovascular Research, 2023 - academic.oup.com
Vascular cell adhesion molecule-1 (VCAM-1) has been well established as a critical
contributor to atherosclerosis and consequently as an attractive therapeutic target for anti …

Novel insights on the role of VCAM-1 and ICAM-1: Potential biomarkers for cardiovascular diseases

R Kaur, V Singh, P Kumari, R Singh… - Annals of Medicine …, 2022 - journals.lww.com
2 the bloodstream without any intermediate steps [14]. These serum markers contributions to
the acute coronary syndrome's inflammatory process, as well as any potential …

Evaluation of VCAM-1 antibodies as therapeutic agent for atherosclerosis in apolipoprotein E-deficient mice

JG Park, SY Ryu, IH Jung, YH Lee, KJ Kang, MR Lee… - Atherosclerosis, 2013 - Elsevier
OBJECTIVE: Blocking agents targeting cell adhesion molecules have been developed to
prevent cardiovascular diseases such as atherosclerosis, whereas relatively little attention …

Vascular cell adhesion molecule‐1: a viable therapeutic target for atherosclerosis?

DJ Preiss, N Sattar - International journal of clinical practice, 2007 - Wiley Online Library
Atherosclerosis is now well recognised as a chronic inflammatory process which may
ultimately lead to myocardial infarction, stroke and peripheral vascular disease. The role of …

Pharmacological blockage of ICAM-1 improves angiotensin II-induced cardiac remodeling by inhibiting adhesion of LFA-1+ monocytes

QY Lin, PP Lang, YL Zhang, XL Yang… - American Journal …, 2019 - journals.physiology.org
Intercellular adhesion molecule-1 (ICAM-1) is a member of an immunoglobulin-like
superfamily of adhesion molecules that mediate leukocyte adhesion to vascular …

Ig-like domain 6 of VCAM-1 is a potential therapeutic target in TNFα-induced angiogenesis

TK Kim, CS Park, HJ Na, K Lee, A Yoon… - … & Molecular Medicine, 2017 - nature.com
Tumor necrosis factor alpha (TNFα)-induced angiogenesis plays important roles in the
progression of various diseases, including cancer, wet age-related macular degeneration …