Heterogeneity within a population is universally observed in all natural systems and
bioprocesses. It is a result from either genetic diversity at population level or phenotypic …

Population heterogeneity among a microbial culture can occur in various stages of a
bioprocess. When a nutrient-limited fed-batch process is applied in the large scale, gradient …

Population heterogeneity is omnipresent in all bioprocesses even in homogenous
environments. Its origin, however, is only so well understood that potential strategies like bet …

The present paper focuses on the development of a population balance model (PBM)
accounting for microbial population dynamics in a fluctuating environment. Heterogeneity …

Cellular heterogeneity influences bioprocess performance in ways that until date are not
completely elucidated. In order to account for this phenomenon in the design and operation …

Successful scale-up of bioprocesses requires that laboratory-scale performance is equally
achieved during large-scale production to meet economic constraints. In industry, heuristic …

With the continuous development, in the last decades, of analytical techniques providing
complex information at single cell level, the study of cell heterogeneity has been the focus of …

The development of a population balance model accounting for cell adaptation to a
fluctuating environment is focussed in this article. In a bioreactor, the substrate concentration …

Microbial cell populations are typically described by averaged properties although individual
cells present a certain degree of variability in properties such as age and mass even when …

In large-scale industrial bioprocesses, the presence of gradients in critical process
parameters, such as dissolved oxygen (DO), pH, and substrate concentration, can be …