[HTML][HTML] Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci
Integrating epigenetic data with genome-wide association study (GWAS) results can reveal
disease mechanisms. The genome sequence itself also shapes the epigenome, with CpG …
disease mechanisms. The genome sequence itself also shapes the epigenome, with CpG …
[HTML][HTML] Genetics of chronic kidney disease stages across ancestries: The PAGE study
BM Lin, GN Nadkarni, R Tao, M Graff, M Fornage… - Frontiers in …, 2019 - frontiersin.org
Background Chronic kidney disease (CKD) is common and disproportionally burdens
United States ethnic minorities. Its genetic determinants may differ by disease severity and …
United States ethnic minorities. Its genetic determinants may differ by disease severity and …
Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney
The kidney is an organ of key relevance to blood pressure (BP) regulation, hypertension and
antihypertensive treatment. However, genetically mediated renal mechanisms underlying …
antihypertensive treatment. However, genetically mediated renal mechanisms underlying …
Unique associations of DNA methylation regions with 24-hour blood pressure phenotypes in black participants
Background: Epigenetic marks (eg, DNA methylation) may capture the effect of gene-
environment interactions. DNA methylation is involved in blood pressure (BP) regulation and …
environment interactions. DNA methylation is involved in blood pressure (BP) regulation and …
Genome-wide association of CKD progression: the chronic renal insufficiency cohort study
The rate of decline of renal function varies significantly among individuals with CKD. To
understand better the contribution of genetics to CKD progression, we performed a genome …
understand better the contribution of genetics to CKD progression, we performed a genome …
Genetic and epigenetic risk factors for diabetic kidney disease
AJ McKnight, GJ McKay, AP Maxwell - Advances in chronic kidney disease, 2014 - Elsevier
Diabetes is increasing at daunting rates worldwide, and approximately 40% of affected
individuals will develop kidney complications. Diabetic kidney disease (DKD) is the leading …
individuals will develop kidney complications. Diabetic kidney disease (DKD) is the leading …
[HTML][HTML] The emerging role of DNA methylation in kidney transplantation: a perspective
Allograft outcome depends on a range of factors, including donor age, the allo-immune
response, ischemia–reperfusion injury, and interstitial fibrosis of the allograft. Changes in …
response, ischemia–reperfusion injury, and interstitial fibrosis of the allograft. Changes in …
Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation
Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to
understand mechanisms underpinning gene regulation and disease. In the present study …
understand mechanisms underpinning gene regulation and disease. In the present study …
[HTML][HTML] Gene-specific DNA methylation association with serum levels of C-reactive protein in African Americans
A more thorough understanding of the differences in DNA methylation (DNAm) profiles in
populations may hold promise for identifying molecular mechanisms through which genetic …
populations may hold promise for identifying molecular mechanisms through which genetic …
Epigenome‐wide study identifies novel methylation loci associated with body mass index and waist circumference
Objective To conduct an epigenome‐wide analysis of DNA methylation and obesity traits.
Methods DNA methylation was quantified in CD4+ T‐cells using the Illumina Infinium …
Methods DNA methylation was quantified in CD4+ T‐cells using the Illumina Infinium …