Improved prediction of MHC II antigen presentation through integration and motif deconvolution of mass spectrometry MHC eluted ligand data
B Reynisson, C Barra, S Kaabinejadian… - Journal of proteome …, 2020 - ACS Publications
Major histocompatibility complex II (MHC II) molecules play a vital role in the onset and
control of cellular immunity. In a highly selective process, MHC II presents peptides derived …
control of cellular immunity. In a highly selective process, MHC II presents peptides derived …
NNAlign_MA; MHC peptidome deconvolution for accurate MHC binding motif characterization and improved T-cell epitope predictions
The set of peptides presented on a cell's surface by MHC molecules is known as the
immunopeptidome. Current mass spectrometry technologies allow for identification of large …
immunopeptidome. Current mass spectrometry technologies allow for identification of large …
[HTML][HTML] MHCflurry 2.0: improved pan-allele prediction of MHC class I-presented peptides by incorporating antigen processing
Computational prediction of the peptides presented on major histocompatibility complex
(MHC) class I proteins is an important tool for studying T cell immunity. The data available to …
(MHC) class I proteins is an important tool for studying T cell immunity. The data available to …
NetMHCpan-4.1 and NetMHCIIpan-4.0: improved predictions of MHC antigen presentation by concurrent motif deconvolution and integration of MS MHC eluted ligand …
Major histocompatibility complex (MHC) molecules are expressed on the cell surface, where
they present peptides to T cells, which gives them a key role in the development of T-cell …
they present peptides to T cells, which gives them a key role in the development of T-cell …
NetMHCpan-4.0: improved peptide–MHC class I interaction predictions integrating eluted ligand and peptide binding affinity data
Cytotoxic T cells are of central importance in the immune system's response to disease.
They recognize defective cells by binding to peptides presented on the cell surface by MHC …
They recognize defective cells by binding to peptides presented on the cell surface by MHC …
NetMHCpan-3.0; improved prediction of binding to MHC class I molecules integrating information from multiple receptor and peptide length datasets
M Nielsen, M Andreatta - Genome medicine, 2016 - Springer
Background Binding of peptides to MHC class I molecules (MHC-I) is essential for antigen
presentation to cytotoxic T-cells. Results Here, we demonstrate how a simple alignment step …
presentation to cytotoxic T-cells. Results Here, we demonstrate how a simple alignment step …
Footprints of antigen processing boost MHC class II natural ligand predictions
Background Major histocompatibility complex class II (MHC-II) molecules present peptide
fragments to T cells for immune recognition. Current predictors for peptide to MHC-II binding …
fragments to T cells for immune recognition. Current predictors for peptide to MHC-II binding …
Accurate MHC motif deconvolution of immunopeptidomics data reveals a significant contribution of DRB3, 4 and 5 to the total DR immunopeptidome
Mass spectrometry (MS) based immunopeptidomics is used in several biomedical
applications including neo-epitope discovery in oncology, next-generation vaccine …
applications including neo-epitope discovery in oncology, next-generation vaccine …
Systematically benchmarking peptide-MHC binding predictors: From synthetic to naturally processed epitopes
W Zhao, X Sher - PLoS computational biology, 2018 - journals.plos.org
A number of machine learning-based predictors have been developed for identifying
immunogenic T-cell epitopes based on major histocompatibility complex (MHC) class I and II …
immunogenic T-cell epitopes based on major histocompatibility complex (MHC) class I and II …
[HTML][HTML] Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes
J Racle, P Guillaume, J Schmidt, J Michaux, A Larabi… - Immunity, 2023 - cell.com
CD4+ T cells orchestrate the adaptive immune response against pathogens and cancer by
recognizing epitopes presented on class II major histocompatibility complex (MHC-II) …
recognizing epitopes presented on class II major histocompatibility complex (MHC-II) …