The rate of decline of renal function varies significantly among individuals with CKD. To
understand better the contribution of genetics to CKD progression, we performed a genome …

Background Rapid progression of CKD is associated with poor clinical outcomes. Despite
extensive study of the genetics of cross-sectional eGFR, only a few loci associated with …

Chronic kidney disease (CKD) is common, affecting about 10% of the general population,
and causing significant morbidity and mortality. Apart from the risk conferred by traditional …

Background The incidence of CKD is associated with genetic factors. However, genetic
markers associated with the progression of CKD have not been fully elucidated. Methods …

Chronic kidney disease (CKD), defined by low estimated glomerular filtration rate (eGFR),
contributes to global morbidity and mortality. Here we conduct a transethnic Genome-Wide …

The past few years have seen major advances in genome-wide association studies (GWAS)
of CKD and kidney function–related traits in several areas: increases in sample size from> …

Background Chronic kidney disease (CKD) is common and disproportionally burdens
United States ethnic minorities. Its genetic determinants may differ by disease severity and …

Chronic kidney disease (CKD) is a significant public health problem, and recent genetic
studies have identified common CKD susceptibility variants. The CKDGen consortium …

Reduced glomerular filtration rate defines chronic kidney disease and is associated with
cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide …

Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-
decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci …