Objective: Despite the fact that exogenous mRNA has great prospects for the development
of therapeutic medicine, its use is still limited. As the immediate protein precursor, positive …

RNA interference (RNAi) represents a form of post-transcriptional gene silencing mediated
by small interfering RNAs (siRNA) and provides a powerful tool to specifically inhibit viral …

We reported a natural antisense (AS) long non-coding RNA as an important modulator of
interferon-Alpha1 (IFNA1) mRNA levels. We showed that IFN-Alpha1 AS promotes IFNA1 …

Nonstructural protein 1 (NS1) of influenza A viruses counteracts the host immune response
against the influenza viruses by not only inhibiting the nuclear export and maturation of host …

Interferon lambda (IFNλ), classified as a type III IFN, is a representative cytokine that plays
an important role in innate immunity along with type I IFN. IFNλ can elicit antiviral states by …

Previously, we identified a set of long noncoding RNAs (lncRNAs) that were differentially
expressed in influenza A virus (IAV)-infected cells. In this study, we focused on lnc-MxA …

Long noncoding RNAs (lncRNAs) are involved in a diversity of biological processes. It is
known that differential expression of thousands of lncRNAs occurs in host during influenza A …

RNA interference (RNAi) is a novel, gene silencing technique that could be valuable in
creating alternatives to antiviral treatments/vaccines and producing virus resistant …

Avian influenza virus H5N1 causes widespread infection in the birds and human respiratory
tract, but existing vaccines and drug therapy are of limited value. Here we show that small …

Influenza B virus is a cause of substantial morbidity and mortality in humans and current
vaccination strategies and antiviral drugs only provide limited protection. Here, we report the …