Background Proximal tubule cells dominate the kidney parenchyma numerically, although
less abundant cell types of the distal nephron have disproportionate roles in water and …

Molecular characterization of the individual cell types in human kidney as well as model
organisms are critical in defining organ function and understanding translational aspects of …

Background Three different cell types constitute the glomerular filter: mesangial cells,
endothelial cells, and podocytes. However, to what extent cellular heterogeneity exists …

Background The glomerulus is a specialized capillary bed that is involved in urine
production and BP control. Glomerular injury is a major cause of CKD, which is epidemic …

Background Proximal tubular cells (PTCs) are the most abundant cell type in the kidney.
PTCs are central to normal kidney function and to regeneration versus organ fibrosis …

The integration of single cell transcriptome and chromatin accessibility datasets enables a
deeper understanding of cell heterogeneity. We performed single nucleus ATAC (snATAC …

A comprehensive cellular anatomy of normal human kidney is crucial to address the cellular
origins of renal disease and renal cancer. Some kidney diseases may be cell type-specific …

Prior RNA sequencing (RNA-seq) studies have identified complete transcriptomes for most
renal epithelial cell types. The exceptions are the cell types that make up the renal collecting …

Kidneys are intricate three-dimensional structures in the body, yet the spatial and molecular
principles of kidney health and disease remain inadequately understood. We generated …

Chronic kidney disease affects 10% of the population with notable differences in ethnic and
sex-related susceptibility to kidney injury and disease. Kidney dysfunction leads to …