Aging as an irretrievable occurrence throughout the entire life is characterized by a
progressive decline in physiological functionality and enhanced disease vulnerability …

The biological markers of aging used to predict physical health status in older people are of
great interest. Telomere shortening, which occurs during the process of cell replication, was …

Aging is the most important risk factor for major human lifestyle diseases, including cancer,
neurological and cardiometabolic disorders. Due to the complex interplay between genetics …

Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …

Age predictors based on DNA methylation levels at a small set of CpG sites, DNAm clocks,
have been developed for humans and extended to several other species. Three currently …

Identifying and validating molecular targets of interventions that extend the human health
span and lifespan has been difficult, as most clinical biomarkers are not sufficiently …

Advanced age is the main common risk factor for cancer, cardiovascular disease and
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …

Background Age-associated DNA methylation changes provide a promising biomarker for
the aging process. While genome-wide DNA methylation profiles enable robust age …

The number of age predictors based on DNA methylation (DNAm) profile is rising due to
their potential in predicting healthspan and application in age-related illnesses, such as …

Human DNA methylation data have been used to develop biomarkers of ageing, referred to
as 'epigenetic clocks', which have been widely used to identify differences between …