Environmental factors including diet, sedentary lifestyle and exposure to pollutants largely
influence human health throughout life. Cellular and molecular events triggered by an …

Abstract Purpose of Review Mitochondria play various roles that are important for cell
function and survival; therefore, significant mitochondrial dysfunction may have chronic …

Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

Mitochondria are critical for the provision of ATP for cellular energy requirements. Tissue
and organ functions are dependent on adequate ATP production, especially when energy …

Significance: Mitochondria are structurally and biochemically diverse, even within a single
type of cell. Protein complexes localized to the inner mitochondrial membrane synthesize …

Mitochondrial function is critical for health, as demonstrated by the effects of mitochondrial
toxicity, mutations in genes encoding mitochondrial proteins, and the role of mitochondrial …

Recent decades have seen a rapid increase in reported toxic effects of drugs and pollutants
on mitochondria. Researchers have also documented many genetic differences leading to …

Mitochondria perform diverse yet interconnected functions, producing ATP and many
biosynthetic intermediates while also contributing to cellular stress responses such as …

The role of mitochondrial function in health and disease has become increasingly
recognized, particularly in the last two decades. Mitochondrial dysfunction as well as …

Background: Cells respond to environmental stressors through several key pathways,
including response to reactive oxygen species (ROS), nutrient and ATP sensing, DNA …