Exercise has multiple beneficial effects including improving peripheral insulin sensitivity,
improving central function such as memory, and restoring a dysregulated blood-brain barrier …

Background Insulin transport across the blood-brain barrier (BBB) is a highly regulated,
saturable process, known to be affected by many peripheral substrates including insulin …

Key points Insulin enters the brain from the blood via a saturable transport system. It is
unclear how insulin is transported across the blood–brain barrier (BBB). Using two models …

Exercise has systemic health benefits in people, in part, through improving whole body
insulin sensitivity. The brain is an insulin-sensitive organ that is often underdiscussed …

Aims/hypothesis For circulating insulin to act on the brain it must cross the blood–brain
barrier (BBB). Remarkably little is known about how circulating insulin crosses the BBB's …

Accumulating evidence suggests there is an alternative insulin transporter besides the
insulin receptor at the blood-brain barrier (BBB), responsible for shuttling insulin from the …

Insulin in the brain acts as a satiety factor, reduces appetite, and decreases body mass.
Altered sensing by brain of insulin may be a leading cause of weight gain and insulin …

Subsequent to the discovery of insulin in 1921, the role of insulin in the brain has been
investigated throughly. The ability of insulin to act within the brain to regulate peripheral …

Introduction CNS insulin levels are decreased and insulin receptor signalling is dampened
in Alzheimer's disease (AD). Increasing CNS insulin levels through a variety of methods has …

The blood-brain barrier (BBB) mediates the communication between the periphery and the
central nervous system (CNS). Recently, CNS insulin resistance has been elucidated to play …