Gene–environment correlations across geographic regions affect genome-wide association studies
Gene–environment correlations affect associations between genetic variants and complex
traits in genome-wide association studies (GWASs). Here we showed in up to 43,516 British …
traits in genome-wide association studies (GWASs). Here we showed in up to 43,516 British …
Allele-specific expression reveals interactions between genetic variation and environment
Identifying interactions between genetics and the environment (GxE) remains challenging.
We have developed EAGLE, a hierarchical Bayesian model for identifying GxE interactions …
We have developed EAGLE, a hierarchical Bayesian model for identifying GxE interactions …
Apparent latent structure within the UK Biobank sample has implications for epidemiological analysis
Large studies use genotype data to discover genetic contributions to complex traits and infer
relationships between those traits. Co-incident geographical variation in genotypes and …
relationships between those traits. Co-incident geographical variation in genotypes and …
Quantification of the overall contribution of gene-environment interaction for obesity-related traits
The growing sample size of genome-wide association studies has facilitated the discovery of
gene-environment interactions (GxE). Here we propose a maximum likelihood method to …
gene-environment interactions (GxE). Here we propose a maximum likelihood method to …
Localising loci underlying complex trait variation using regional genomic relationship mapping
Y Nagamine, R Pong-Wong, P Navarro, V Vitart… - 2012 - journals.plos.org
The limited proportion of complex trait variance identified in genome-wide association
studies may reflect the limited power of single SNP analyses to detect either rare causative …
studies may reflect the limited power of single SNP analyses to detect either rare causative …
Genetic correlates of social stratification in Great Britain
A Abdellaoui, D Hugh-Jones, L Yengo… - Nature human …, 2019 - nature.com
Human DNA polymorphisms vary across geographic regions, with the most commonly
observed variation reflecting distant ancestry differences. Here we investigate the …
observed variation reflecting distant ancestry differences. Here we investigate the …
Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects
Estimates from genome-wide association studies (GWAS) of unrelated individuals capture
effects of inherited variation (direct effects), demography (population stratification …
effects of inherited variation (direct effects), demography (population stratification …
The E is in the G: gene–environment–trait correlations and findings from Genome-Wide Association Studies
R Avinun - Perspectives on Psychological Science, 2020 - journals.sagepub.com
Genome-wide association studies (GWASs) have shown that pleiotropy is widespread (ie,
the same genetic variants affect multiple traits) and that complex traits are polygenic (ie …
the same genetic variants affect multiple traits) and that complex traits are polygenic (ie …
Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank
Genotype-by-environment interaction (GEI) is a fundamental component in understanding
complex trait variation. However, it remains challenging to identify genetic variants with GEI …
complex trait variation. However, it remains challenging to identify genetic variants with GEI …
[PDF][PDF] Genetic interactions drive heterogeneity in causal variant effect sizes for gene expression and complex traits
Despite the growing number of genome-wide association studies (GWASs), it remains
unclear to what extent gene-by-gene and gene-by-environment interactions influence …
unclear to what extent gene-by-gene and gene-by-environment interactions influence …