Although molecular features underlying aging and species maximum lifespan (MLS) have
been comprehensively studied by transcriptome analyses, the actual impact of transcriptome …

Background The biological mechanisms that underlie aging have not yet been fully
identified. Senescence, a phenomenon occurring in vitro, limits the number of cell divisions …

One of the important questions in aging research is how differences in transcriptomics are
associated with the longevity of various species. Unfortunately, at the level of individual …

Ageing leads to dramatic changes in the physiology of many different tissues resulting in a
spectrum of pathology. Nonetheless, many lines of evidence suggest that ageing is driven …

Genome-wide studies of aging have identified subsets of genes that show age-related
changes in expression. Although the types of genes that are age regulated vary among …

Studies of age-related molecular profiles have separately focused on the human and rodent
brains, but the extent to which each organism predicts molecular events across species for …

Aging is among the most important risk factors for morbidity and mortality. To contribute
toward a molecular understanding of aging, we analyzed age-resolved transcriptomic data …

Mammals differ more than 100‐fold in maximum lifespan, which can be altered in either
direction during evolution, but the molecular basis for natural changes in longevity is not …

It is well established that gene expression levels in many organisms change during the
aging process, and the advent of DNA microarrays has allowed genome-wide patterns of …

Studies in invertebrate model organisms have been a driving force in aging research,
leading to the identification of many genes that influence life span. Few of these genes have …