Assessment of a large panel of candidate biomarkers of ageing in the Newcastle 85+ study

C Martin-Ruiz, C Jagger, A Kingston, J Collerton… - Mechanisms of ageing …, 2011 - Elsevier
Sensitive and specific biomarkers of ageing are needed to evaluate interventions to extend
health span. However, there is growing evidence that information provided by candidate …

[HTML][HTML] Distinct biological ages of organs and systems identified from a multi-omics study

C Nie, Y Li, R Li, Y Yan, D Zhang, T Li, Z Li, Y Sun… - Cell reports, 2022 - cell.com
Biological age (BA) has been proposed to evaluate the aging status instead of chronological
age (CA). Our study shows evidence that there might be multiple" clocks" within the whole …

A synopsis on aging—Theories, mechanisms and future prospects

JP da Costa, R Vitorino, GM Silva, C Vogel… - Ageing research …, 2016 - Elsevier
Answering the question as to why we age is tantamount to answering the question of what is
life itself. There are countless theories as to why and how we age, but, until recently, the very …

Biological Versus Chronological Aging: JACC Focus Seminar

MR Hamczyk, RM Nevado, A Barettino, V Fuster… - Journal of the American …, 2020 - jacc.org
Aging is the main risk factor for vascular disease and ensuing cardiovascular and
cerebrovascular events, the leading causes of death worldwide. In a progressively aging …

A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup

JN Justice, L Ferrucci, AB Newman, VR Aroda… - Geroscience, 2018 - Springer
Recent advances indicate that biological aging is a potentially modifiable driver of late-life
function and chronic disease and have led to the development of geroscience-guided …

Human ageing as a dynamic, emergent and malleable process: from disease-oriented to health-oriented approaches

PP Chmielewski - Biogerontology, 2020 - Springer
Over the decades, biogerontology has matured as a scientific discipline. Currently, a number
of theoretical frameworks are available to researchers when interpreting empirical data …

Musculoskeletal system in the old age and the demand for healthy ageing biomarkers

S Collino, FP Martin, LG Karagounis… - Mechanisms of ageing …, 2013 - Elsevier
Population ageing has emerged as a major demographic trend worldwide due to improved
health and longevity. This global ageing phenomenon will have a major impact on health …

Undulating changes in human plasma proteome profiles across the lifespan

B Lehallier, D Gate, N Schaum, T Nanasi, SE Lee… - Nature medicine, 2019 - nature.com
Aging is a predominant risk factor for several chronic diseases that limit healthspan.
Mechanisms of aging are thus increasingly recognized as potential therapeutic targets …

Advances and challenges in geroscience research: an update

A Yabluchanskiy, Z Ungvari, A Csiszar… - Physiology …, 2018 - akjournals.com
Aging remains the most pervasive risk factor for a wide range of chronic diseases that afflict
modern societies. In the United States alone, incidence of age-related diseases (eg …

A novel statistical approach shows evidence for multi-system physiological dysregulation during aging

AA Cohen, E Milot, J Yong, CL Seplaki, T Fülöp… - Mechanisms of ageing …, 2013 - Elsevier
Previous studies have identified many biomarkers that are associated with aging and related
outcomes, but the relevance of these markers for underlying processes and their …