Epigenetic clocks for mice were generated based on deep-sequencing analysis of the
methylome. Here, we demonstrate that site-specific analysis of DNA methylation levels by …

Aging is characterized by numerous molecular changes, such as accumulation of molecular
damage and altered gene expression, many of which are linked to DNA methylation. Here …

Recent research efforts provided compelling evidence of genome-wide DNA methylation
alterations in aging and age-related disease. It is currently well established that DNA …

Epigenetic alterations pose one major hallmark of organismal aging. Here, we provide an
overview on recent findings describing the epigenetic changes that arise during aging and …

Recent studies have demonstrated that the DNA methylome changes with age. This
epigenetic drift may have deep implications for cellular differentiation and disease …

The process of aging results in a host of changes at the cellular and molecular levels, which
include senescence, telomere shortening, and changes in gene expression. Epigenetic …

Aging is a pleiotropic process affecting many aspects of mammalian physiology. Mammals
are composed of distinct cell type identities and tissue environments, but the influence of …

Epigenetic clocks have come to be regarded as powerful tools for estimating aging.
However, a major drawback in their application is our lack of mechanistic understanding. We …

Background Mammalian species exhibit a wide range of lifespans. To date, a robust and
dynamic molecular readout of these lifespan differences has not yet been identified. Recent …

Age predictors based on DNA methylation levels at a small set of CpG sites, DNAm clocks,
have been developed for humans and extended to several other species. Three currently …