DNA methylation clocks in aging: categories, causes, and consequences
Age-associated changes to the mammalian DNA methylome are well documented and
thought to promote diseases of aging, such as cancer. Recent studies have identified …
thought to promote diseases of aging, such as cancer. Recent studies have identified …
A multi-omics longitudinal aging dataset in primary human fibroblasts with mitochondrial perturbations
Aging is a process of progressive change. To develop biological models of aging,
longitudinal datasets with high temporal resolution are needed. Here we report a multi …
longitudinal datasets with high temporal resolution are needed. Here we report a multi …
“Epigenetic clocks”: Theory and applications in human biology
CP Ryan - American Journal of Human Biology, 2021 - Wiley Online Library
All humans age, but how we age—and how fast—differs considerably from person to
person. This deviation between apparent age and chronological age is often referred to as …
person. This deviation between apparent age and chronological age is often referred to as …
Tracking the epigenetic clock across the human life course: a meta-analysis of longitudinal cohort data
Background Epigenetic clocks based on DNA methylation yield high correlations with
chronological age in cross-sectional data. Due to a paucity of longitudinal data, it is not …
chronological age in cross-sectional data. Due to a paucity of longitudinal data, it is not …
Decoding aging hallmarks at the single-cell level
S Ma, X Chi, Y Cai, Z Ji, S Wang, J Ren… - Annual Review of …, 2023 - annualreviews.org
Organismal aging exhibits wide-ranging hallmarks in divergent cell types across tissues,
organs, and systems. The advancement of single-cell technologies and generation of rich …
organs, and systems. The advancement of single-cell technologies and generation of rich …
DunedinPACE, a DNA methylation biomarker of the pace of aging
Background: Measures to quantify changes in the pace of biological aging in response to
intervention are needed to evaluate geroprotective interventions for humans. Previously, we …
intervention are needed to evaluate geroprotective interventions for humans. Previously, we …
Epigenetic clocks reveal a rejuvenation event during embryogenesis followed by aging
The notion that the germ line does not age goes back to the 19th-century ideas of August
Weismann. However, being metabolically active, the germ line accumulates damage and …
Weismann. However, being metabolically active, the germ line accumulates damage and …
Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions
JJ Cole, NA Robertson, MI Rather, JP Thomson… - Genome biology, 2017 - Springer
Background Age-associated epigenetic changes are implicated in aging. Notably, age-
associated DNA methylation changes comprise a so-called aging “clock”, a robust …
associated DNA methylation changes comprise a so-called aging “clock”, a robust …
Underlying features of epigenetic aging clocks in vivo and in vitro
Epigenetic clocks, developed using DNA methylation data, have been widely used to
quantify biological aging in multiple tissues/cells. However, many existing epigenetic clocks …
quantify biological aging in multiple tissues/cells. However, many existing epigenetic clocks …
Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing
Background DNA methylation changes with age. Chronological age predictors built from
DNA methylation are termed 'epigenetic clocks'. The deviation of predicted age from the …
DNA methylation are termed 'epigenetic clocks'. The deviation of predicted age from the …