In the developing Drosophila optic lobe, neuroepithelial (NE) cells are transformed
progressively into neurogenic progenitors called neuroblasts (NBs). The progenitors …

In order for neural progenitors (NPs) to generate distinct populations of neurons at the right
time and place during CNS development, they must switch from undergoing purely …

It is firmly established that interactions between neurons and glia are fundamental across
species for the correct establishment of a functional brain. Here, we found that the glia of the …

Background Neural stem cells generate all of the neurons and glial cells in the central
nervous system, both during development and in the adult to maintain homeostasis. In the …

Reason for Erratum: Due to a typesetting error the spelling of a few terms was incorrect in
“Notch Signaling” Section, paragraph 4. This error does not change the scientific …

Proneural genes were initially identified in Drosophila, where pioneer work on these
important regulators of neural development was performed, and from which the term …

The first step in the development of the Drosophila optic medullar primordia is the expansion
of symmetrically dividing neuroepithelial cells (NEs); this step is then followed by the …

A dynamic balance between stem cell maintenance and differentiation paces generation of
post‐mitotic progeny during normal development and maintenance of homeostasis. Recent …

Background ASC/ASCL proneural transcription factors are oncogenic and exhibit impressive
reprogramming and pioneer activities. In both Drosophila and mammals, these factors are …

In the developing Drosophila central nervous system (CNS), neural progenitor (neuroblast
[NB]) selection is gated by lateral inhibition, controlled by Notch signaling and proneural …