Diabetic retinopathy (DR) is the leading cause of blindness in working age Americans.
Clinicians diagnose DR based on its characteristic vascular pathology, which is evident …

Retinal neovascularization is a leading cause of visual disability. Retinal diseases involving
neovascularization all follow the same progression, beginning with vascular inflammatory …

We have shown previously that diabetes causes increases in retinal arginase activity that
are associated with impairment of endothelial cell (EC)-dependent vasodilation and …

Ischemic retinopathies represent a major cause of visual impairment and blindness. They
include diabetic retinopathy (DR), acute glaucoma, retinopathy of prematurity (ROP), and …

Aims/hypothesis A reduction in retinal blood flow occurs early in diabetes and is likely to be
involved in the development of diabetic retinopathy. We hypothesise that activation of the …

Ischemic retinopathies, such as diabetic retinopathy (DR), retinopathy of prematurity and
retinal vein occlusion are a major cause of blindness in developed nations worldwide. Each …

Arginase is a ubiquitous enzyme in the urea cycle (UC) that hydrolyzes L‐arginine to urea
and L‐ornithine. Two mammalian arginase isoforms, arginase1 (ARG1) and arginase2 …

Arginase has been reported to reduce nitric oxide bioavailability in cardiovascular disease.
However, its specific role in retinopathy has not been studied. In this study, we assessed the …

The lack of effective therapies to limit neurovascular injury in ischemic retinopathy is a major
clinical problem. This study aimed to examine the role of ureohydrolase enzyme, arginase 1 …

Diabetes mellitus is a major risk factor for the development of cardiovascular disease due to
increased vascular inflammatory and oxidative stress favouring atherogenesis. Endothelial …