SUMMARY 1 Nitric oxide (NO) plays a fundamental role in the vasculature because of its
diverse influence in vascular protection, including its well‐reported antiproliferative, anti …

There is growing evidence that vascular arginase plays a role in pathophysiology of
vascular diseases. We recently reported high arginase activity/expression in young adult …

There is a growing evidence that arginase has a role in the pathophysiology of
cardiovascular diseases including hypertension. We recently reported arginase …

This study investigated the temporal activation of arginase in obese Zucker rats (ZR) and
determined if arginase inhibition prevents the development of hypertension and improves …

Purpose To determine if plasma levels of six arginine-related and citrulline-related
metabolites (arginine, citrulline, asymmetric dimethylarginine [ADMA], ornithine, proline, and …

Objectives: The development of microvascular complications in diabetes is a complex
process in which endothelial dysfunction is important. Emerging evidence suggests that …

Purpose: To determine plasma metabolite and metabolic pathway differences between
patients with type 2 diabetes with diabetic retinopathy (DR) and without retinopathy (diabetic …

Background Arginase is implicated in the pathogenesis behind endothelial dysfunction in
type 2 diabetes mellitus (T2 DM) by its inhibition of nitric oxide formation. Strict glycaemic …

Diabetes-induced increase in oxidative stress is postulated as playing a significant role in
the development of retinopathy. The retinal pigment epithelium (RPE) which forms part of the …

Background—Endothelial dysfunction plays an important role in the early development of
atherosclerosis and vascular complications in type 2 diabetes mellitus. Increased …