ARGINASE: A CRITICAL REGULATOR OF NITRIC OXIDE SYNTHESIS AND VASCULAR
FUNCTION - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI …

Objective.–Arginase is a nitric oxide synthase-alternative pathway for l-arginine breakdown
leading to biosynthesis of urea and l-ornithine. Arginase pathway is inducible by …

Background There is great interest to understand causal pathophysiological correlation
between obesity and diabetes mellitus (DM). Vascular endothelial dysfunction is crucially …

Oxidized low-density lipoproteins increase arginase activity and reciprocally decrease
endothelial NO in human aortic endothelial cells. Here, we demonstrate that vascular …

Increased arginase activity has been reported in a variety of disease conditions
characterized by vascular dysfunction. In the present study, the potentially protective effect of …

Diabetic retinopathy (DR), commonly classified as a microvascular complication of diabetes,
is now recognized as a neurovascular complication or sensory neuropathy resulting from …

Background and Purpose Emerging evidence suggests a selective up‐regulation of
arginase I in diabetes causing coronary artery disease; however, the mechanisms behind …

Background Elevated arginase (Arg) activity is reported to be involved in diabetes-induced
vascular endothelial dysfunction. It can reduce L-arginine availability to nitric oxide (NO) …

Background—Although abnormal l-arginine NO signaling contributes to endothelial
dysfunction in the aging cardiovascular system, the biochemical mechanisms remain …

Background Retinopathy of prematurity (ROP) is a major cause of vision impairment in low
birth weight infants. While previous work has focused on defining the mechanisms of …