Cardiac fibroblasts (CF) play an important role in the healing process and in pathological
remodeling of cardiac tissue. As sentinel cells in the heart, they respond to inflammatory …

Aims Despite the broad pharmacological arsenal to treat hypertension, chronic patients may
develop irreversible cardiac remodeling and fibrosis. Angiotensin II, the main peptide …

Cardiac fibroblasts (CFs) have a key role in the inflammatory response after cardiac injury
and are necessary for wound healing. Resolvins are potent agonists that control the duration …

Background: Resolution of inflammation is orchestrated by specialized proresolving lipid
mediators (SPMs), and this would be impaired in some cardiovascular diseases. Among …

Increased inflammation is the key mechanism that mediates sepsis induced cardiac injury.
Resolvin D1 (RvD1), a bioactive lipid mediator synthesized from docosahexaenoic acid, can …

The proliferation, migration and phenotypic transformation of vascular smooth muscle cells
contribute to vascular remodeling and hypertension. Resolvin D1 (RvD1) is a specialized …

Unresolved inflammation is a major contributor to the development of heart failure following
myocardial infarction (MI). Pro-resolving lipid mediators, such as resolvins (eg RvD1), are …

Lung ischemia-reperfusion injury (LIRI) is still an unsolved medical issue, which negatively
affects the prognosis of many lung diseases. The aim of this study is to determine the effects …

Background To investigate the protective effect of resolvin D1 (RvD1) on aortic dissection
(AD) in mice and explore the related mechanisms. Methods Mice were randomly divided into …

Recent evidence suggests that specialized lipid mediators derived from polyunsaturated
fatty acids control resolution of inflammation, but little is known about resolution pathways in …