Diabetes mellitus is a major risk factor for the development of cardiovascular disease due to
increased vascular inflammatory and oxidative stress favouring atherogenesis. Endothelial …

Endothelial dysfunction represents an early change in the vascular wall in areas prone to
atherosclerotic plaque formation and is present in association with several risk factors for …

Functional integrity of the vascular endothelium is of fundamental importance for normal
vascular function. A key factor regulating endothelial function is the bioavailability of nitric …

Coronary artery disease (CAD) remains the leading cause of death in the Western societies.
Diabetes mellitus (DM) is one of the highly prevalent diseases, which remarkably …

Background: Endothelial dysfunction contributes to the development of vascular
complication in diabetes. Arginase has emerged as a key mechanism behind endothelial …

Decreased endothelial nitric oxide (NO) bioavailability as it relates to endothelial dysfunction
plays an important role in various cardiovascular disorders, including atherosclerosis …

Background—Endothelial dysfunction plays an important role in the early development of
atherosclerosis and vascular complications in type 2 diabetes mellitus. Increased …

Endothelial dysfunction is a characteristic feature in diabetes that contributes to the
development of vascular disease. Recently, arginase has been implicated in triggering …

Aims Elevation of arginase activity has been linked to vascular dysfunction in diabetes and
hypertension by a mechanism involving decreased nitric oxide (NO) bioavailability due to L …

Endothelial dysfunction and resulting vascular pathology have been identified as an early
hallmark of multiple diseases, including diabetes mellitus. One of the major contributors to …