Arginase can cause vascular dysfunction by competing with nitric oxide synthase for l-
arginine and by increasing cell proliferation and collagen formation, which promote vascular …

Background—Although abnormal l-arginine NO signaling contributes to endothelial
dysfunction in the aging cardiovascular system, the biochemical mechanisms remain …

Oxidized low-density lipoprotein (OxLDL) impairs NO signaling and endothelial function,
and contributes to the pathogenesis of atherosclerosis. Arginase reciprocally regulates NO …

Background Arginase competes with nitric oxide synthase for their common substrate L-
arginine. Up-regulation of arginase in coronary artery disease (CAD) and diabetes mellitus …

Emerging evidence suggests that arginase contributes to endothelial dysfunction in
diabetes. Intracellular signaling pathways, which interplay between arginase and eNOS …

Increases in arginase activity have been reported in a variety of disease conditions
characterized by vascular dysfunction. Arginase competes with NO synthase for their …

Background Cardiovascular disorders associated with endothelial dysfunction, such as
atherosclerosis, have decreased nitric oxide (NO) bioavailability. Arginase in the vasculature …

The endothelial production of nitric oxide (NO) mediates endothelium-dependent
vasorelaxation and restrains vascular inflammation, smooth muscle cell proliferation, and …

Objectives: The development of microvascular complications in diabetes is a complex
process in which endothelial dysfunction is important. Emerging evidence suggests that …

Arginase is a metalloenzyme which hydrolyzes L‐arginine to L‐ornithine and urea. Since its
discovery, in the early 1900s, this enzyme has gained increasing attention, as literature …