Arginase-2 counteracts endothelial nitric oxide synthase (eNOS) activity in human
endothelium, and its expression is negatively controlled by histone deacetylase (HDAC2) …

Background Cigarette smoke increases the risk of several cardiovascular diseases and has
synergistic detrimental effects when present with other risks that contribute to its …

Arginase has roots in early life-forms. It converts L-arginine to urea and ornithine. The former
provides protection against NH 3; the latter serves to stimulate cell growth and other …

Atherosclerotic vascular disease is the leading cause of morbidity and mortality in
developed countries. While it is a complex condition resulting from numerous genetic and …

Arginase is upregulated in some tissues under diabetes states. Arginase can compete with
nitroxide synthase (NOS) for the common substrate L-arginine and thus increases oxidative …

Overproduction of reactive oxygen species, ie, oxidative stress, is associated with the
activation of redox signaling pathways linking to inflammatory insults and cardiovascular …

This study is an attempt to find whether arginine metabolism dysregulation by arginase
activity is related to hyperglycemia, followed by changes in nitric oxide (NO) generation in …

Background Elevated LDL cholesterol is an important risk factor for atherosclerosis.
Endothelial dysfunction, an early event in the development of atherosclerosis, is …

It is well known that arginase II leads to decreased synthesis of nitric oxide (NO) by
competing with endothelial nitric oxide synthase (eNOS) for their same substrate l-arginine …

Two distinct enzymes of arginase (1 and 2) are critically regulating nitric oxide (NO)
bioavailability by competing with NO synthase for their common substrate l-arginine …