Vascular and associated ventricular stiffness is one of the hallmarks of the aging
cardiovascular system. Both an increase in reactive oxygen species production and a …

[Frontiers in Bioscience S3, 946-960, June 1, 2011] 946 Endothelial dysfunction in hypertension:
The role of arginase Danielle L Page 1 [Frontiers in Bioscience S3, 946-960, June 1, 2011] 946 …

Growing evidence suggests that increased arginase activity affects vital bioprocesses in
various systems and universally mediates the pathogenesis of numerous metabolic …

Purpose: Retinal vasomotor activity can be regulated by two major endothelial enzymes,
nitric oxide synthase (NOS) and cyclooxygenase (COX). The vascular arginase also …

Abstract l-Arginine is the common substrate for nitric oxide synthases (NOS) and arginase.
Whereas the contribution of NOS to collateral artery growth (arteriogenesis) has been …

OBJECTIVE: Alterations of wall shear stress can predispose the endothelium to the
development of atherosclerotic plaques. Ample evidence indicates that arginase expression …

Abstract Arginase 1 (Arg1) is a ubiquitous enzyme belonging to the urea cycle that catalyzes
the conversion of l-arginine into l-ornithine and urea. In endothelial cells (ECs), Arg1 was …

Recently, we showed that pharmacological blockade or genetic deficiency of arginase-2
confers kidney protection in diabetic mouse models. Here, we tested whether the protective …

Aims Increased matrix metalloproteinases activity and reduced nitric oxide (NO)
bioavailability contributes to development of hypertension and this may be associated with a …

Diabetes is associated with cardiac inflammation and impaired endothelium-dependent
coronary vasodilation, but molecular mechanisms involved in this dysfunction remain …