Stress sensitization to depression following childhood adversity: Moderation by HPA axis and serotonergic multilocus profile scores
Childhood adversity appears to sensitize youth to stress, increasing depression risk
following stressful life events occurring throughout the lifespan. Some evidence suggests …
following stressful life events occurring throughout the lifespan. Some evidence suggests …
HPA-axis multilocus genetic variation moderates associations between environmental stress and depressive symptoms among adolescents
Research suggests that genetic variants linked to hypothalamic-pituitary-adrenal (HPA)-axis
functioning moderate the association between environmental stressors and depression, but …
functioning moderate the association between environmental stressors and depression, but …
The effects of childhood maltreatment, recent interpersonal and noninterpersonal stress, and HPA-axis multilocus genetic variation on prospective changes in …
K Sun, C Cao - Development and psychopathology, 2024 - cambridge.org
Based on a multiwave, two-year prospective design, this study is the first to examine the
extent to which multilocus hypothalamic–pituitary–adrenal axis (HPA axis)-related genetic …
extent to which multilocus hypothalamic–pituitary–adrenal axis (HPA axis)-related genetic …
Interpersonal childhood adversity and stress generation in adolescence: Moderation by HPA axis multilocus genetic variation
Research suggests that childhood adversity (CA) is associated with a wide range of
repercussions, including an increased likelihood of interpersonal stress generation. This …
repercussions, including an increased likelihood of interpersonal stress generation. This …
Childhood maltreatment, multilocus HPA-axis genetic variation and adolescent comorbidity profiles of depressive and anxiety symptoms
C Cao, M Chen, S Yang, Y Xu, J Gu - Child Abuse & Neglect, 2024 - Elsevier
Background Despite a growing body of evidence showing both genetic and environmental
influences on adolescent depression and anxiety, the involved comorbid mechanisms …
influences on adolescent depression and anxiety, the involved comorbid mechanisms …
Mechanisms of gene–environment interactions in depression: evidence that genes potentiate multiple sources of adversity
M Wichers, D Schrijvers, N Geschwind… - Psychological …, 2009 - cambridge.org
BackgroundPrevious work suggests that daily life stress-sensitivity may be an intermediary
phenotype associated with both genetic risk for depression and developmental stress …
phenotype associated with both genetic risk for depression and developmental stress …
Serotonergic multilocus genetic variation moderates the association between major interpersonal stress and adolescent depressive symptoms: Replication and …
Serotonin-linked genetic risk and stressful life event (SLE) interaction research has been
criticized for using single genetic variants with inconsistent replicability. A recent study …
criticized for using single genetic variants with inconsistent replicability. A recent study …
Associations between depression-relevant genetic risk and youth stress exposure: Evidence of gene–environment correlations.
Familial risk for depression is associated with youth exposure to self-generated dependent
stressful life events and independent events that are out of youth's control. Familial risk …
stressful life events and independent events that are out of youth's control. Familial risk …
Hypothalamic-pituitary-adrenal axis genetic variation and early stress moderates amygdala function
CR Di Iorio, CE Carey, LJ Michalski… - …, 2017 - Elsevier
Early life stress may precipitate psychopathology, at least in part, by influencing amygdala
function. Converging evidence across species suggests that links between childhood stress …
function. Converging evidence across species suggests that links between childhood stress …
Disentangling gene‐environment correlations and interactions on adolescent depressive symptoms
Background: Genetic risks for depression may be expressed through greater exposure
towards environmental stressors (gene–environment correlation, rGE) and increased …
towards environmental stressors (gene–environment correlation, rGE) and increased …