The liver and gallbladder are among the most important internal organs derived from the
endoderm, yet the development of the liver and gallbladder in the early embryonic stages is …

The definitive endoderm (DE) is the embryonic germ layer that forms the gut tube and
associated organs, including thymus, lungs, liver and pancreas. To understand how …

Dear Editor, Members of Foxa transcription factor family, namely Foxa1, Foxa2, and Foxa3,
play crucial roles in guiding hepatic differentiation and hepatic homeostatic maintenance (Le …

Hepatic differentiation at the molecular level is poorly understood, mainly because of the
lack of a suitable model. Recently, using adherent monoculture conditions, we demonstrated …

Understanding the biological potential of fetal stem/progenitor cells will help define
mechanisms in liver development and homeostasis. We isolated epithelial fetal human liver …

Although endodermal organs including the liver, pancreas, and intestine are of significant
therapeutic interest, the mechanism by which the endoderm is divided into organ domains …

Complex cross-talk between endoderm and the microenvironment is an absolute
requirement to orchestrate hepatic specification and expansion. In the mouse, the septum …

Genetic analysis, embryonic tissue explantation and in vivo chromatin studies have together
identified the distinct regulatory steps that are necessary for the development of endoderm …

The definitive endoderm forms during gastrulation and is rapidly transformed into the gut
tube which is divided along the anterior–posterior axis into the foregut, midgut, and hindgut …

Background During embryogenesis the liver is derived from endodermal cells lining the
digestive tract. These endodermal progenitor cells contribute to forming the parenchyma of a …