Embryonic definitive endoderm (DE) generates the epithelial compartment of vital organs
such as liver, pancreas, and intestine. However, purification of DE in mammals has not been …

The adult liver of most vertebrates is predominantly comprised of hepatocytes. However,
these cells must work in concert with biliary, stellate, vascular, and immune cells to …

Little is known about how the endoderm germ layer is patterned along the anterior–posterior
(A‐P) axis before the formation of a gut tube (embryonic day [e] 7.5–8.5 in mouse), largely …

Elucidating the molecular mechanisms involved in the differentiation of stem cells to hepatic
cells is critical for both understanding normal developmental processes as well as for …

The forkhead box f1 (Foxf1) transcription factor is expressed in septum transversum
mesenchyme and splanchnic (visceral) mesoderm, which give rise to mesenchymal cells of …

During development, liver undergoes a rapid transition from a hematopoietic organ to a
major organ for drug metabolism and nutrient homeostasis. However, little is known on a …

Fibroblast growth factors (FGFs) are required to specify hepatic fate within the definitive
endoderm through activation of the FGF receptors (FGFRs). While the signaling pathways …

The liver performs a number of essential functions for life. The development of such a
complex organ relies on finely regulated gene expression profiles which change over time in …

Generation of hepatocyte from embryonic stem cells (ESCs) holds great promise for
hepatocyte replacement therapy to treat liver diseases. Achieving high efficiency of directed …

Defining the precise regionalization of specified definitive endoderm progenitors is critical
for understanding the mechanisms underlying the generation and regeneration of …