Sexual maturation is a complex physiological process that involves multiple variables, such
as genetic and environmental factors. Among females, age at menarche (AM) is a critical …

Age at menarche (AAM) is a complex trait involving both genetic and environmental factors.
To identify the genetic factors associated with AAM, we conducted a large-scale meta …

To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide
association studies in 87,802 women of European descent, with replication in up to 14,731 …

BACKGROUND Menarche is the first menstrual period of a girl at puberty. The timing of
menarche is important for health in later life. Age at menarche is a complex trait and has a …

African-American (AA) women have earlier menarche on average than women of European
ancestry (EA), and earlier menarche is a risk factor for obesity and type 2 diabetes among …

Objective An early onset of menarche and, later, menopause are well-established risk
factors for the development of breast cancer and endometrial cancer. Although the largest …

Context: Age at menarche (AAM) is an important anthropological variable that has major
implications for a woman's health later in life. Genetic influence has been shown to …

Age at menarche (AM) and age at natural menopause (ANM) are complex traits with a high
heritability. Abnormal timing of menarche or menopause is associated with a reduced span …

We conducted a meta-analysis of genome-wide association data to detect genes influencing
age at menarche in 17,510 women. The strongest signal was at 9q31. 2 (P= 1.7× 10− 9) …

Introduction Many diseases of adulthood are associated with a woman's age at menarche.
Genetic variation affects age at menarche, but it remains unclear whether in women of …