methylclock: a Bioconductor package to estimate DNA methylation age
D Pelegí-Sisó, P De Prado, J Ronkainen… - …, 2021 - academic.oup.com
Motivation Ageing is a biological and psychosocial process related to diseases and
mortality. It correlates with changes in DNA methylation (DNAm) in all human tissues …
mortality. It correlates with changes in DNA methylation (DNAm) in all human tissues …
[HTML][HTML] A pan-tissue DNA-methylation epigenetic clock based on deep learning
Several age predictors based on DNA methylation, dubbed epigenetic clocks, have been
created in recent years, with the vast majority based on regularized linear regression. This …
created in recent years, with the vast majority based on regularized linear regression. This …
Universal DNA methylation age across mammalian tissues
Aging is often perceived as a degenerative process resulting from random accrual of cellular
damage over time. Despite this, age can be accurately estimated by epigenetic clocks based …
damage over time. Despite this, age can be accurately estimated by epigenetic clocks based …
[HTML][HTML] Multi-tissue DNA methylation age predictor in mouse
Background DNA methylation changes at a discrete set of sites in the human genome are
predictive of chronological and biological age. However, it is not known whether these …
predictive of chronological and biological age. However, it is not known whether these …
[HTML][HTML] Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing
Background DNA methylation changes with age. Chronological age predictors built from
DNA methylation are termed 'epigenetic clocks'. The deviation of predicted age from the …
DNA methylation are termed 'epigenetic clocks'. The deviation of predicted age from the …
[HTML][HTML] DNA methylation age of human tissues and cell types
S Horvath - Genome biology, 2013 - Springer
Background It is not yet known whether DNA methylation levels can be used to accurately
predict age across a broad spectrum of human tissues and cell types, nor whether the …
predict age across a broad spectrum of human tissues and cell types, nor whether the …
[HTML][HTML] DeepMAge: a methylation aging clock developed with deep learning
DNA methylation aging clocks have become an invaluable tool in biogerontology research
since their inception in 2013. Today, a variety of machine learning approaches have been …
since their inception in 2013. Today, a variety of machine learning approaches have been …
Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex
GL Shireby, JP Davies, PT Francis, J Burrage… - Brain, 2020 - academic.oup.com
Human DNA methylation data have been used to develop biomarkers of ageing, referred to
as 'epigenetic clocks', which have been widely used to identify differences between …
as 'epigenetic clocks', which have been widely used to identify differences between …
[HTML][HTML] Insights into ageing rates comparison across tissues from recalibrating cerebellum DNA methylation clock
DNA methylation (DNAm)-based age clocks have been studied extensively as a biomarker
of human ageing and a risk factor for age-related diseases. Despite different tissues having …
of human ageing and a risk factor for age-related diseases. Despite different tissues having …
[HTML][HTML] Functional genomics analysis identifies T and NK cell activation as a driver of epigenetic clock progression
Background Epigenetic clocks use DNA methylation (DNAm) levels of specific sets of CpG
dinucleotides to accurately predict individual chronological age. A popular application of …
dinucleotides to accurately predict individual chronological age. A popular application of …