Background Children exposed to social adversity carry a greater risk of poor physical and mental health into adulthood. This increased risk is thought to be due, in part, to …
Background No study has investigated the role of inflammation in explaining the association between early exposures to adverse life events and depressive symptoms in adolescence …
This study provides a comprehensive review of the published research on the association between early life adversity and markers of inflammation in children and adolescents. We …
Stress in early life has been associated with insufficient glucocorticoid signaling in adulthood, possibly affecting inflammation processes. Childhood maltreatment has been …
A Danese, TE Moffitt, HL Harrington… - … of pediatrics & …, 2009 - jamanetwork.com
Objective To understand why children exposed to adverse psychosocial experiences are at elevated risk for age-related disease, such as cardiovascular disease, by testing whether …
Psychological stress during childhood and adolescence increases risk of health problems across the lifecourse, and inflammation is implicated as an underlying mechanism. To …
We examined the joint contributions of self-reported adverse childhood experiences (ACEs) and recent life events (RLEs) to inflammation at midlife, by testing 3 competing theoretical …
Adverse childhood experiences (ACEs) are associated with depression and systemic inflammation in adults. However, limited longitudinal research has tested these relationships …
M Chen, RE Lacey - Brain, behavior, and immunity, 2018 - Elsevier
Background The relationship between adverse childhood experiences (ACE) and poorer health across the life course is well established. Increased chronic inflammation might be …