Considerations for drug interactions on QTc in exploratory COVID-19 treatment

DM Roden, RA Harrington, A Poppas, AM Russo - Circulation, 2020 - Am Heart Assoc
1. Chen CY, Wang FL, Lin CC. Chronic hydroxychloroquine use associated with QT
prolongation and refractory ventricular arrhythmia. Clin Toxicol (Phila). 2006; 44: 173–175 …

Considerations for drug interactions on QTc interval in exploratory COVID-19 treatment

DM Roden, RA Harrington, A Poppas… - Journal of the American …, 2020 - jacc.org
Hydroxychloroquine and azithromycin have been touted for potential prophylaxis or
treatment for patients with coronavirus disease 2019 (COVID-19). Both drugs are listed as …

Chloroquine-induced QTc prolongation in COVID-19 patients

MPH Van den Broek, JE Möhlmann, BGS Abeln… - Netherlands Heart …, 2020 - Springer
Background In the battle against the SARS-CoV‑2 pandemic, chloroquine has emerged as a
new potential therapeutic option for the treatment of infected patients. A safety consideration …

QT prolongation, torsades de pointes, and sudden death with short courses of chloroquine or hydroxychloroquine as used in COVID-19: A systematic review

L Jankelson, G Karam, ML Becker, LA Chinitz, MC Tsai - Heart rhythm, 2020 - Elsevier
Chloroquine and hydroxychloroquine are now being widely used for treatment of COVID-19.
Both medications prolong the QT interval and accordingly may put patients at increased risk …

[HTML][HTML] Cardiac toxicity of chloroquine or hydroxychloroquine in patients with COVID-19: a systematic review and meta-regression analysis

IM Tleyjeh, Z Kashour, O AlDosary, M Riaz… - … : Innovations, Quality & …, 2021 - Elsevier
Objective To systematically review the literature and to estimate the risk of chloroquine (CQ)
and hydroxychloroquine (HCQ) cardiac toxicity in patients with coronavirus disease 2019 …

QTc prolongation in COVID‐19 patients treated with hydroxychloroquine, chloroquine, azithromycin, or lopinavir/ritonavir: a systematic review and meta‐analysis

C Diaz‐Arocutipa, A Brañez‐Condorena… - … and Drug Safety, 2021 - Wiley Online Library
Purpose Hydroxychloroquine, chloroquine, azithromycin, and lopinavir/ritonavir are drugs
that were used for the treatment of coronavirus disease 2019 (COVID‐19) during the early …

Assessment of QT intervals in a case series of patients with coronavirus disease 2019 (COVID-19) infection treated with hydroxychloroquine alone or in combination …

F Bessière, H Roccia, A Delinière, P Chevalier… - JAMA …, 2020 - jamanetwork.com
© 2020 American Medical Association. All rights reserved. favoring prolonged QT. The QTc
interval was continuously monitored; an electrocardiogram (ECG) was recorded daily. All …

[HTML][HTML] The QT interval in patients with COVID-19 treated with hydroxychloroquine and azithromycin

E Chorin, M Dai, E Shulman, L Wadhwani… - Nature medicine, 2020 - nature.com
To the Editor—The SARS-CoV-2 pandemic has caused more than 1.6 million positive cases
and more than 95,000 confirmed deaths as of 10 April 2020 (ref. 1). Although there are no …

Risk of QT interval prolongation associated with use of hydroxychloroquine with or without concomitant azithromycin among hospitalized patients testing positive for …

NJ Mercuro, CF Yen, DJ Shim, TR Maher… - JAMA …, 2020 - jamanetwork.com
Importance Administration of hydroxychloroquine with or without azithromycin for the
treatment of coronavirus disease 2019 (COVID-19)–associated pneumonia carries …

Effect of chloroquine, hydroxychloroquine, and azithromycin on the corrected QT interval in patients with SARS-CoV-2 infection

M Saleh, J Gabriels, D Chang, B Soo Kim… - Circulation …, 2020 - Am Heart Assoc
Background: The novel SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is
responsible for the global coronavirus disease 2019 pandemic. Small studies have shown a …