The viral protein NSP1 acts as a ribosome gatekeeper for shutting down host translation and fostering SARS-CoV-2 translation

A Tidu, A Janvier, L Schaeffer, P Sosnowski, L Kuhn… - Rna, 2021 - rnajournal.cshlp.org
SARS-CoV-2 coronavirus is responsible for the Covid-19 pandemic. In the early phase of
infection, the single-strand positive RNA genome is translated into nonstructural proteins …

The key features of SARS-CoV-2 leader and NSP1 required for viral escape of NSP1-mediated repression

L Bujanic, O Shevchuk, N von Kügelgen, A Kalinina… - Rna, 2022 - rnajournal.cshlp.org
SARS-CoV-2, responsible for the ongoing global pandemic, must overcome a conundrum
faced by all viruses. To achieve its own replication and spread, it simultaneously depends …

Targeting stem-loop 1 of the SARS-CoV-2 5′ UTR to suppress viral translation and Nsp1 evasion

SM Vora, P Fontana, T Mao, V Leger… - Proceedings of the …, 2022 - National Acad Sciences
SARS-CoV-2 is a highly pathogenic virus that evades antiviral immunity by interfering with
host protein synthesis, mRNA stability, and protein trafficking. The SARS-CoV-2 …

[HTML][HTML] SARS-CoV-2 Nsp1 suppresses host but not viral translation through a bipartite mechanism

M Shi, L Wang, P Fontana, S Vora, Y Zhang, TM Fu… - BioRxiv, 2020 - ncbi.nlm.nih.gov
SUMMARY The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a
highly contagious virus that underlies the current COVID-19 pandemic. SARS-CoV-2 is …

Universal features of Nsp1-mediated translational shutdown by coronaviruses

K Schubert, ED Karousis, I Ban, CP Lapointe… - Molecular cell, 2023 - cell.com
Summary Nonstructural protein 1 (Nsp1) produced by coronaviruses inhibits host protein
synthesis. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Nsp1 C …

I(nsp1)ecting SARS-CoV-2–ribosome interactions

M Simeoni, T Cavinato, D Rodriguez… - Communications …, 2021 - nature.com
While SARS-CoV-2 is causing modern human history's most serious health crisis and
upending our way of life, clinical and basic research on the virus is advancing rapidly …

The N-terminal domain of SARS-CoV-2 nsp1 plays key roles in suppression of cellular gene expression and preservation of viral gene expression

AS Mendez, M Ly, AM González-Sánchez, E Hartenian… - Cell Reports, 2021 - cell.com
Summary Nonstructural protein 1 (nsp1) is a coronavirus (CoV) virulence factor that restricts
cellular gene expression by inhibiting translation through blocking the mRNA entry channel …

SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation

K Schubert, ED Karousis, A Jomaa, A Scaiola… - Nature structural & …, 2020 - nature.com
Abstract The SARS-CoV-2 non-structural protein 1 (Nsp1), also referred to as the host
shutoff factor, suppresses host innate immune functions. By combining cryo-electron …

Dynamic competition between SARS-CoV-2 NSP1 and mRNA on the human ribosome inhibits translation initiation

CP Lapointe, R Grosely, AG Johnson… - Proceedings of the …, 2021 - National Acad Sciences
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a beta-CoV that recently
emerged as a human pathogen and is the causative agent of the COVID-19 pandemic. A …

[HTML][HTML] Nonstructural protein 1 of SARS-CoV-2 is a potent pathogenicity factor redirecting host protein synthesis machinery toward viral RNA

S Yuan, L Peng, JJ Park, Y Hu, SC Devarkar, MB Dong… - Molecular cell, 2020 - cell.com
The causative virus of the COVID-19 pandemic, SARS-CoV-2, uses its nonstructural protein
1 (Nsp1) to suppress cellular, but not viral, protein synthesis through yet unknown …