Arginase can cause vascular dysfunction by competing with nitric oxide synthase for l-
arginine and by increasing cell proliferation and collagen formation, which promote vascular …

Aims Elevation of arginase activity has been linked to vascular dysfunction in diabetes and
hypertension by a mechanism involving decreased nitric oxide (NO) bioavailability due to L …

Background Cardiovascular disorders associated with endothelial dysfunction, such as
atherosclerosis, have decreased nitric oxide (NO) bioavailability. Arginase in the vasculature …

Enhanced vascular arginase activity impairs endothelium-dependent vasorelaxation by
decreasing l-arginine availability to endothelial nitric oxide (NO) synthase, thereby reducing …

Oxidized low-density lipoproteins increase arginase activity and reciprocally decrease
endothelial NO in human aortic endothelial cells. Here, we demonstrate that vascular …

Arginase metabolizes the semi-essential amino acid l-arginine to l-ornithine and urea. There
are two distinct isoforms of arginase, arginase I and II, which are encoded by separate …

Background—Although abnormal l-arginine NO signaling contributes to endothelial
dysfunction in the aging cardiovascular system, the biochemical mechanisms remain …

Diabetes mellitus is a major risk factor for the development of cardiovascular disease due to
increased vascular inflammatory and oxidative stress favouring atherogenesis. Endothelial …

Enhanced vascular arginase activity can impair endothelium-dependent vasorelaxation by
decreasing l-arginine availability to endothelial nitric oxide (NO) synthase, thereby reducing …

Background Elevated arginase (Arg) activity is reported to be involved in diabetes-induced
vascular endothelial dysfunction. It can reduce L-arginine availability to nitric oxide (NO) …