Mitochondria are the central target of ischemic preconditioning and postconditioning
cardioprotective strategies, which consist of either the application of brief intermittent …

Several interventions, such as ischemic preconditioning, remote pre/perconditioning, or
postconditioning, are known to decrease lethal myocardial ischemia-reperfusion injury …

Pharmacologic cardiac conditioning increases the intrinsic resistance against ischemia and
reperfusion (I/R) injury. The cardiac conditioning response is mediated via complex …

Tissues with high-energy turnover, such as heart mus-cle, heavily depend on ATP produced
by mitochondrial oxidative phosphorylation, and therefore display particular vulnerability to …

The heart is a highly energy-dependent organ, and most of its energy is provided by
mitochondrial oxidative phosphorylation. Therefore, maintaining a well-functioning …

Vascular pathologies pose a significant health problem because of their wide prevalence
and high impact on the rate of mortality. Blockade of blood flow in major blood vessels leads …

Mitochondrial damage is a critical contributor to cardiac ischemia/reperfusion (I/R) injury.
Mitochondrial quality control (MQC) mechanisms, a series of adaptive responses that …

Thrombolytic therapy and revascularization strategies create a complete recanalization of
the occluded epicardial coronary artery in patients with myocardial infarction (MI). However …

Mitochondria are increasingly recognized as lynchpins in the evolution of cardiac injury
during ischemia and reperfusion. This review addresses the emerging concept that …

Despite considerable efforts to prevent and treat ischemic cardiomyopathy (ICM), effective
therapies remain lacking, in part owing to the complexity of the underlying molecular …