The first antiplatelet agent used in clinical medicine was aspirin. Derived from willow bark, its
medicinal properties were first recognised 3 500 years ago by the Sumerians and Egyptians …

Already more than two thousands years ago the Greek physician Hippocrates (V-IV century
BC) used the extracts of the willow bark to fight fever. At the end of the eighteen hundreds …

When introduced over 100 years ago, aspirin was prescribed as an analgesic drug to
arthritic patients for pain relief. The prevalence of users grew quite rapidly and to this day …

Clinical trials of salicylates date back to the Eighteenth century. This compound is naturally
present in the bark of willow (botanical name, Salicaceae) and the Reverend Edward Stone …

The story of the discovery of aspirin stretches back more than 3500 years to when bark from
the willow tree was used as a pain reliever and antipyretic. It involves an Oxfordshire …

The synthesis of aspirin in the late nineteenth century marked the development of what was
to become the most widely used household analgesic in the twentieth century. However …

Clinical trials of antiplatelet agents in patients with vascular disease have had a major
impact on medical practice. Aspirin has been shown to be effective for both primary and …

Aspirin is one of the oldest and most commonly used nonprescription drugs in the world.
Although commonly it is used for relief from common headache and muscular pain, its use in …

Aspirin is widely used for its analgesic and antiinflammatory properties, and increasingly in
recent years as antithrombotic treatment. Daily doses of 75–150 mg eVectively inhibit the …

Thrombotic occlusion is one of the chief complications of coronary atherosclerosis. The
search for an effective method to prevent coronary thrombosis has thus been an active …