Aims Growing evidence suggests that arginase misregulation plays a key role in the
pathophysiology of essential hypertension. In the present study, we investigated the …

Objective High vascular arginase activity and subsequent reduction in vascular nitric oxide
production were recently reported in animal models of hypertension. The present study …

Objective A decrease in nitric oxide (NO) bioavailability has been proposed to contribute to
endothelial dysfunction and increased peripheral resistances during essential arterial …

There is growing evidence that vascular arginase plays a role in pathophysiology of
vascular diseases. We recently reported high arginase activity/expression in young adult …

Background and Purpose We have previously shown that arginase inhibition alleviates
hypertension associated with in a diabetic animal model. Here, we investigated the …

Objective This study investigated whether arginase contributes to endothelial dysfunction
and hypertension in obese rats. Methods Endothelial function and arginase expression were …

Growing evidence suggests that increased arginase activity affects vital bioprocesses in
various systems and universally mediates the pathogenesis of numerous metabolic …

Arginase upregulation is associated with aging and cardiovascular diseases. In this study
we report on the cardiovascular phenotype of the arginase II knockout (KO) mouse. We …

Arginase can cause vascular dysfunction by competing with nitric oxide synthase for l-
arginine and by increasing cell proliferation and collagen formation, which promote vascular …

Arginase may play a major role in the regulation of vascular function in various
cardiovascular disorders by impairing nitric oxide (NO) production. In the current study, we …