Prediction of Alzheimer's disease using multi-variants from a Chinese genome-wide association study

L Jia, F Li, C Wei, M Zhu, Q Qu, W Qin, Y Tang, L Shen… - Brain, 2021 - academic.oup.com
Previous genome-wide association studies have identified dozens of susceptibility loci for
sporadic Alzheimer's disease, but few of these loci have been validated in longitudinal …

Polygenic risk and hazard scores for Alzheimer's disease prediction

G Leonenko, R Sims, M Shoai, A Frizzati… - Annals of clinical …, 2019 - Wiley Online Library
Objective Genome‐wide association studies (GWAS) have identified over 30 susceptibility
loci associated with Alzheimer's disease (AD). Using AD GWAS data from the International …

Common polygenic variation enhances risk prediction for Alzheimer's disease

V Escott-Price, R Sims, C Bannister, D Harold… - Brain, 2015 - academic.oup.com
The identification of subjects at high risk for Alzheimer's disease is important for prognosis
and early intervention. We investigated the polygenic architecture of Alzheimer's disease …

[HTML][HTML] Risk prediction for sporadic Alzheimer's disease using genetic risk score in the Han Chinese population

Q Xiao, ZJ Liu, S Tao, YM Sun, D Jiang, HL Li… - Oncotarget, 2015 - ncbi.nlm.nih.gov
More than 30 independent single-nucleotide polymorphisms (SNPs) have been associated
with Alzheimer's disease (AD) risk by genome-wide association studies (GWAS) in …

Genetic risk for alzheimer disease is distinct from genetic risk for amyloid deposition

G Leonenko, M Shoai, E Bellou, R Sims… - Annals of …, 2019 - Wiley Online Library
Objective Alzheimer disease (AD) is the most common form of dementia and is responsible
for a huge and growing health care burden in the developed and developing world. The …

Genome-wide association analysis of age-at-onset in Alzheimer's disease

MI Kamboh, MM Barmada, FY Demirci, RL Minster… - Molecular …, 2012 - nature.com
The risk of Alzheimer's disease (AD) is strongly determined by genetic factors and recent
genome-wide association studies (GWAS) have identified several genes for the disease risk …

An overview of genome-wide association studies in Alzheimer's disease

L Shen, J Jia - Neuroscience bulletin, 2016 - Springer
Genome-wide association studies (GWASs) have revealed a plethora of putative
susceptibility genes for Alzheimer's disease (AD). With the sole exception of the APOE gene …

Associations of Alzheimer's disease risk variants with gene expression, amyloidosis, tauopathy, and neurodegeneration

MS Tan, YX Yang, W Xu, HF Wang, L Tan… - Alzheimer's Research & …, 2021 - Springer
Background Genome-wide association studies have identified more than 30 Alzheimer's
disease (AD) risk genes, although the detailed mechanism through which all these genes …

Current status on Alzheimer disease molecular genetics: from past, to present, to future

K Bettens, K Sleegers… - Human molecular …, 2010 - academic.oup.com
Linkage studies, candidate gene and whole-genome association studies have resulted in a
tremendous amount of putative risk genes for Alzheimer's disease (AD). Yet, besides the …

Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers

Y Deming, Z Li, M Kapoor, O Harari, JL Del-Aguila… - Acta …, 2017 - Springer
More than 20 genetic loci have been associated with risk for Alzheimer's disease (AD), but
reported genome-wide significant loci do not account for all the estimated heritability and …