SARS-CoV-2 spike protein induces cognitive deficit and anxiety-like behavior in mouse via non-cell autonomous hippocampal neuronal death

J Oh, WH Cho, E Barcelon, KH Kim, J Hong, SJ Lee - Scientific reports, 2022 - nature.com
… We explored the possibility that the brain-infiltrating SARS-CoV-2 spike … behavioral study
showed that administration of SARS-CoV-2 spike protein S1 subunit (S1 protein) to mouse

SARS-CoV-2 Spike protein induces TLR4-mediated long-term cognitive dysfunction recapitulating post-COVID-19 syndrome in mice

FL Fontes-Dantas, GG Fernandes, EG Gutman… - Cell reports, 2023 - cell.com
… Evidence suggests that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Spike … Here, we demonstrate that brain infusion of Spike protein in mice has a late impact on …

[HTML][HTML] SARS-CoV-2 consequences for mental health: Neuroinflammatory pathways linking COVID-19 to anxiety and depression

AJ de Mello, M Moretti… - World Journal of Psychiatry, 2022 - ncbi.nlm.nih.gov
… α in mice resulted in depressive-like behavior, whereas TNF-α receptor 1 knockout mice
exhibited antidepressant-like behavior in … of TNF-α induced anxiety-related behavior in mice[55]. …

SARS-CoV-2 infection in the mouse olfactory system

Q Ye, J Zhou, Q He, RT Li, G Yang, Y Zhang, SJ Wu… - Cell discovery, 2021 - nature.com
mouse model to demonstrate that SARS-CoV-2 … SARS-CoV-2 infection is the cause of
olfactory dysfunction and anosmia in COVID-19 patients 5,6,22,23 . SARS-CoV-2-infected mice

Mouse models for the study of SARS-CoV-2 infection

AC Knight, SA Montgomery, CA Fletcher… - Comparative …, 2021 - ingentaconnect.com
… -2 infection of the CNS and the potential long-term effects on behavior and neurologic
health… Virus was also detected in the brains of these mice, with the S protein of SARSCoV-2 …

SARS-CoV-2 infection, neuropathogenesis and transmission among deer mice: Implications for spillback to New World rodents

A Fagre, J Lewis, M Eckley, S Zhan, SM Rocha… - PLoS …, 2021 - journals.plos.org
… A significant concern is that SARS-CoV-2 could become … challenged deer mice (Peromyscus
maniculatus) with SARS-CoV-2 … behavioral signs were observed in the current study, SARS-…

Administration of aerosolized SARS-CoV-2 to K18-hACE2 mice uncouples respiratory infection from fatal neuroinvasion

V Fumagalli, M Ravà, D Marotta, P Di Lucia… - Science …, 2021 - science.org
… respiratory tract of SARS-CoV-2–infected K18-hACE2 transgenic mice. We detected
comparable amounts of SARS-CoV-2 RNA and infectious virus from the lungs of mice infected with …

[HTML][HTML] SARS-CoV-2 infection of sustentacular cells disrupts olfactory signaling pathways

AK Verma, J Zheng, DK Meyerholz, S Perlman - JCI insight, 2022 - ncbi.nlm.nih.gov
… , both caused by highly pathogenic human CoV infections, we infected mice with MERS-CoV
or SARS-… Assessment of olfactory behavior and scent discrimination in MERS-CoV–infected …

Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy

H Gu, Q Chen, G Yang, L He, H Fan, YQ Deng, Y Wang… - Science, 2020 - science.org
… Such mice have been used previously to study SARS-CoV-2 … generation of a mouse-adapted
strain of SARS-CoV-2 that … in wild-type immunocompetent mice. Additionally, the protective …

Establishment and characterization of an hACE2/hTMPRSS2 knock-in mouse model to study SARS-CoV-2

H Liu, T Brostoff, A Ramirez, T Wong… - Frontiers in …, 2024 - frontiersin.org
mice, we characterized acute SARS-CoV-2 infection dynamics and long-term changes in
physiology, behavior, … KI survive SARS-CoV-2 infection, and male but not female mice develop …